5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine

Base Information

Chemical Name:5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine
CAS No.:119813-87-5
Molecular Formula:C₁₈H₂₆N₂O₃S
Molecular Weight:350.482
Hs Code.:
Mol file:119813-87-5.mol

Synonyms:6H-Isoquino[2,1-g][1,6]naphthyridine,5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-, (8aa,12aa,13aa)-(?à)-;6H-Isoquino[2,1-g][1,6]naphthyridine,5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-, (8aa,12aa,13aa)-; RS 15385-196

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine

Chemical Property:

Vapor Pressure:2.02E-10mmHg at 25°C
Boiling Point:507.5°Cat760mmHg
Flash Point:260.7°C
PSA：58.23000
Density:1.29g/cm³
LogP:2.99490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine

There total 12 articles about 5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14446-29-8
6-Methoxy-3,4-dihydroisoquinoline

: 119813-87-5,119905-05-4,121961-55-5,129214-09-1,131346-52-6,131346-53-7
(8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino<2,1-g><1,6>naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / LDA / tetrahydrofuran / -40 °C

2: 60 percent / H₂ / Rh-Al₂O₃ / acetic acid

3: LiAlH₄ / tetrahydrofuran

4: NEt₃ / CH₂Cl₂

With lithium aluminium tetrahydride; hydrogen; triethylamine; lithium diisopropyl amide; rhodium on alumina; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00129a002

Reference yield:

: 60511-47-9
2-methylnicotinic acid diethylamide

: 119813-87-5,119905-05-4,121961-55-5,129214-09-1,131346-52-6,131346-53-7
(8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino<2,1-g><1,6>naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / LDA / tetrahydrofuran / -40 °C

2: 60 percent / H₂ / Rh-Al₂O₃ / acetic acid

3: LiAlH₄ / tetrahydrofuran

4: NEt₃ / CH₂Cl₂

With lithium aluminium tetrahydride; hydrogen; triethylamine; lithium diisopropyl amide; rhodium on alumina; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00129a002

Reference yield:

: 119813-94-4
5,8,13,13a-tetrahydro-3-methoxy-8-oxo-6H-isoquino<2,1-g><1,6>naphthyridine

: 119813-87-5,119905-05-4,121961-55-5,129214-09-1,131346-52-6,131346-53-7
(8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino<2,1-g><1,6>naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / H₂ / Rh-Al₂O₃ / acetic acid

2: LiAlH₄ / tetrahydrofuran

3: NEt₃ / CH₂Cl₂

With lithium aluminium tetrahydride; hydrogen; triethylamine; rhodium on alumina; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00129a002