1,5-Pentane-d10-diol

Base Information

• Chemical Name: 1,5-Pentane-d10-diol
• CAS No.: 1219804-42-8
• Molecular Formula: HO(CD2)5OH
• Molecular Weight: 114.21
• Mol file: 1219804-42-8.mol

Synonyms:

Chemical Property of 1,5-Pentane-d10-diol

Chemical Property:

• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

1,5-Pentane-d10-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Labelled version of 1,5-Pentanediol (P273405(P)), which is used as a reagent in the total synthesis of (+)-Rubriflordilactone A, a nortriterpenoid natural product. 1,5-Pentanediol is also the starting material in the synthesis of Pseudomonic Acid D Sodium (P839520); an antibiotic isolated from Pseudomonas fluorescens.

Technology Process of 1,5-Pentane-d10-diol

There total 2 articles about 1,5-Pentane-d10-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2H6-pentanedioic acid (154184-99-3) → 1,5-pentanediol-d10 (1219804-42-8)

Guidance literature:

With lithium aluminium deuteride; In tetrahydrofuran; Heating;

DOI:10.1021/jp040135h

Reference yield:

1,5-pentanedioic acid (110-94-1) → 1,5-pentanediol-d10 (1219804-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / methanol / pH 8.0

1.2: NaOH; D₂O / Pt/C / Heating

2.1: LiAlD₄ / tetrahydrofuran / Heating

With sodium hydroxide; lithium aluminium deuteride; In tetrahydrofuran; methanol;

DOI:10.1021/jp040135h

Reference yield:

1,5-pentanediol-d10 (1219804-42-8) → 1,5-dibromopentane-d10 (1219802-90-0,1219803-90-3)

Guidance literature:

With phosphorus tribromide; Heating;

DOI:10.1021/jp040135h

upstream raw materials:

2H₆-pentanedioic acid

1,5-pentanedioic acid

Downstream raw materials:

1,5-dibromopentane-d10