6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID

Base Information

• Chemical Name: 6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID
• CAS No.: 1015856-57-1
• Molecular Formula: C16H13D5FN3O3
• Molecular Weight: 324.36
• Mol file: 1015856-57-1.mol

Synonyms:6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID;NORFLOXACIN-D5;Norfloxacin-D5 hydrate (see Data Sheet);Noroxacin D5

Chemical Property of 6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID

Chemical Property:

• PSA: 74.57000
• LogP: 1.66210
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli

Purity/Quality:

NLT 98% ^*data from raw suppliers

Norfloxacin-d5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections.

Technology Process of 6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID

There total 4 articles about 6-FLUORO-1,4-DIHYDRO-4-OXO-1-PENTADEUTEROETHYL-7-PIPERAZINO-3-QUINOLINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + C12H4(2)H5F2NO3 → norfloxacin-D5 (1015856-57-1)

Guidance literature:

With pyridine; at 110 ℃; for 5h;

Reference yield:

3,4-difluoroaniline (3863-11-4) → norfloxacin-D5 (1015856-57-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 3 h / 120 - 130 °C

2: diphenylether / 2 h / 240 - 280 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

4: acetic acid; hydrogenchloride / water / 5 h / 100 °C

5: pyridine / 5 h / 110 °C

With pyridine; hydrogenchloride; potassium carbonate; acetic acid; In diphenylether; water; N,N-dimethyl-formamide;

Reference yield:

diethyl 2-[(3,4-difluorophenylamino)methylene]malonate (142354-87-8) → norfloxacin-D5 (1015856-57-1)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenylether / 2 h / 240 - 280 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

3: acetic acid; hydrogenchloride / water / 5 h / 100 °C

4: pyridine / 5 h / 110 °C

With pyridine; hydrogenchloride; potassium carbonate; acetic acid; In diphenylether; water; N,N-dimethyl-formamide;

upstream raw materials:

piperazine

3,4-difluoroaniline

diethyl 2-[(3,4-difluorophenylamino)methylene]malonate

6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Refernces