beta-phenylpropionyl-L-phenylalanine

Base Information

• Chemical Name: beta-phenylpropionyl-L-phenylalanine
• CAS No.: 21888-30-2
• Molecular Formula: C18H19 N O3
• Molecular Weight: 297.354
• Hs Code.: 2924299090
• Mol file: 21888-30-2.mol

Synonyms:Alanine,N-hydrocinnamoyl-3-phenyl-, L- (8CI);3-Phenyl-(2S)-(3-phenylpropanoylamino)propanoic acid; 3-Phenylpropionyl-L-phenylalanine;N-(3-Phenylpropionyl)-L-phenylalanine; N-b-Phenylpropionyl-L-phenylalanine; b-Phenylpropionyl-L-phenylalanine

Chemical Property of beta-phenylpropionyl-L-phenylalanine

Chemical Property:

• Vapor Pressure: 3.61E-13mmHg at 25°C
• Boiling Point: 555.4°Cat760mmHg
• Flash Point: 289.7°C
• PSA: 69.89000
• Density: 1.189g/cm³
• LogP: 3.27160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of beta-phenylpropionyl-L-phenylalanine

There total 11 articles about beta-phenylpropionyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-phenyl-2-(3-phenylpropionylamino)propionic acid methyl ester (21888-31-3) → β-phenylpropionyl-L-phenylalanine (21888-30-2)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Ambient temperature;

DOI:10.1021/jm00052a002

Reference yield: 97.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + 3-Phenylpropionic acid (501-52-0) → β-phenylpropionyl-L-phenylalanine (21888-30-2)

Guidance literature:

3-Phenylpropionic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Green chemistry;

L-phenylalanine; With water; In tetrahydrofuran; at 0 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent; Green chemistry;

DOI:10.1016/j.tetasy.2016.11.009

Reference yield: 70.0%

3-phenyl-2-(R)-(3-phenyl-propionylamino)-propionic acid (54759-61-4) → β-phenylpropionyl-L-phenylalanine (21888-30-2)

Guidance literature:

In ethanol; for 12h;

upstream raw materials:

3-phenyl-2-(3-phenylpropionylamino)propionic acid methyl ester

L-phenylalanine

hydrocinnamic acid chloride

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

(S)-N-(2-Oxo-tetrahydro-thiophen-3-yl)-3-phenyl-2-(3-phenyl-propionylamino)-propionamide

C₃₂H₃₉N₃O₄

Refernces

• 1、 Ezawa, Tetsuya,Jung, Seunghee,Kawashima, Yuya,Noguchi, Takuya,Imai, Nobuyuki. "Convenient green preparation of dipeptides using unprotected α-amino acids". . p. 75 - 83. Retrieved 2017/01/10.
• 2、 Shang, Luqing,Fang, Hao,Zhu, Huawei,Wang, Xuejian,Wang, Qiang,Mu, Jiajia,Wang, Binghe,Kishioka, Shiroh,Xu, Wenfang. "Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors". experimental part. p. 2775 - 2784. Retrieved 2009/08/15.