4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine

Base Information

Chemical Name:4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine
CAS No.:133256-50-5
Molecular Formula:C12H13N3
Molecular Weight:199.25
Hs Code.:
Mol file:133256-50-5.mol

Synonyms:4-METHYL-6-(4-METHYLPHENYL)PYRIMIDIN-2-AMINE;4-METHYL-6-P-TOLYLPYRIMIDIN-2-AMINE

Suppliers and Price of 4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-METHYL-6-PERA-TOLYLPYRIMIDIN-2-AMINE 95.00%
10G
$ 7882.88

American Custom Chemicals Corporation
4-METHYL-6-PERA-TOLYLPYRIMIDIN-2-AMINE 95.00%
5G
$ 4244.63

American Custom Chemicals Corporation
4-METHYL-6-PERA-TOLYLPYRIMIDIN-2-AMINE 95.00%
1G
$ 1030.84

Total 4 raw suppliers

Chemical Property of 4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine

Chemical Property:

Melting Point:149-150 °C
Boiling Point:405.7±53.0 °C(Predicted)
PKA:4.42±0.10(Predicted)
PSA：51.80000
Density:1.132±0.06 g/cm3(Predicted)
LogP:2.92380

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-METHYL-6-PERA-TOLYLPYRIMIDIN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine

There total 5 articles about 4-Methyl-6-(4-methylphenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 2?(methanesulfonyl)?4?methyl?6?(4?methylphenyl)pyrimidine

: 133256-50-5
4?methyl?6?(4?methylphenyl)pyrimidin?2?amine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; at 120 ℃; for 3h; Microwave irradiation;
DOI:10.1007/s00706-020-02674-7

Reference yield:

: 6?methyl?4?(4?methylphenyl)?3,4?dihydropyrimidine?2(1H)?thione

: 133256-50-5
4?methyl?6?(4?methylphenyl)pyrimidin?2?amine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2: chloroform / 72 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

4: ammonium hydroxide / 1,4-dioxane / 3 h / 120 °C / Microwave irradiation

With ammonium hydroxide; sulfur; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; chloroform;
DOI:10.1007/s00706-020-02674-7

Reference yield:

: 4?methyl?6?(4?methylphenyl)?2?(methylsulfanyl)pyrimidine hydroiodide

: 133256-50-5
4?methyl?6?(4?methylphenyl)pyrimidin?2?amine

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2: ammonium hydroxide / 1,4-dioxane / 3 h / 120 °C / Microwave irradiation

With ammonium hydroxide; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1007/s00706-020-02674-7