(3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one

Base Information

Chemical Name:(3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one
CAS No.:955407-70-2
Molecular Formula:C24H22Cl2FN3O
Molecular Weight:458.363
Hs Code.:
Mol file:955407-70-2.mol

Synonyms:BANHLDNYUGHSRY-VTBWFHPJSA-N;(3R)-3-(3,5-Dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-2-one;(3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one

Chemical Property:

PSA：48.99000
LogP:5.40900

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one

There total 6 articles about (3R)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-1-(4,5,6,7-tetrahydro-2H-indazol-6-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 955406-55-0
trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-6-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955406-54-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 1765-93-1
4-fluoroboronic acid

: 955407-70-2
(3R)-3-(3,5-Dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-2-one

Guidance literature:: trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-6-yl)-pyrrolidin-3-ylmethyl]-phenyl ester; trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-3-ylmethyl]-phenyl ester; 4-fluoroboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 80 ℃; for 1h;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955407-70-2
(3R)-3-(3,5-Dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; acetonitrile / 0.5 h / 20 °C

1.2: 18 h

2.1: methanesulfonic acid / dimethylsulfide / 18 h / 20 °C

2.2: pH 7

3.1: pyridine / 1.75 h / 0 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 80 °C

4.2: 20 °C

With pyridine; methanesulfonic acid; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dimethylsulfide; dichloromethane; water; acetonitrile;

Reference yield:

: 955373-72-5
(R)-4-benzyl-3-[(S)-2-(4-benzyloxy-2,6-dichloro-benzyl)-pent-4-enoyl]-oxazolidin-2-onecf

: 955407-70-2
(3R)-3-(3,5-Dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-6-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

2.1: dichloromethane; acetonitrile / 0.5 h / 20 °C

2.2: 18 h

3.1: methanesulfonic acid / dimethylsulfide / 18 h / 20 °C

3.2: pH 7

4.1: pyridine / 1.75 h / 0 - 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 80 °C

5.2: 20 °C

With pyridine; sodium periodate; methanesulfonic acid; sodium carbonate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dimethylsulfide; dichloromethane; water; acetonitrile; tert-butyl alcohol;