1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea

Base Information

• Chemical Name: 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
• CAS No.: 1155877-97-6
• Molecular Formula: C21H19ClN2O2
• Molecular Weight: 366.847
• Hs Code.: 2924299090
• Mol file: 1155877-97-6.mol

Synonyms:UNII-4T436CO8BT;[4-(3'-Chloro-6-methoxy-biphenyl-3-ylmethyl)-phenyl]-urea;Urea,N-(4-((3'-chloro-6-methoxy(1,1'-biphenyl)-3-yl)methyl)phenyl);1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;

Chemical Property of 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea

Chemical Property:

• Boiling Point: 502.0±50.0 °C(Predicted)
• PKA: 14.48±0.50(Predicted)
• PSA: 65.34000
• Density: 1.263±0.06 g/cm3(Predicted)
• LogP: 5.68380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

D-159687 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-159687 is a selective inhibitor of cyclic AMP phosphodiesterase 4D (PDE4D).

Technology Process of 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea

There total 8 articles about 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-(4-(3-bromo-4-methoxybenzyl)phenyl)urea (1155877-96-5) + 3-chlorophenylboronic acid (63503-60-6) → 1-(4-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea (1155877-97-6)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 16h;

DOI:10.1016/j.tetlet.2013.03.063

Reference yield: 56.0%

C20H18ClNO (1158237-26-3) + sodium isocyanate (917-61-3) → 1-(4-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea (1155877-97-6)

Guidance literature:

With acetic acid; In water; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2013.03.063

Reference yield:

3-(3’-chlorophenyl)-4-methoxybenzyl alcohol (1160472-69-4) → 1-(4-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea (1155877-97-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water

3: iron; acetic acid / ethanol / 2 h / 85 °C

4: acetic acid / water / 18 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; acetic acid; triphenylphosphine; In ethanol; dichloromethane; water; 2: |Suzuki Coupling;

DOI:10.1016/j.tetlet.2013.03.063

upstream raw materials:

1-(4-(3-bromo-4-methoxybenzyl)phenyl)urea

3-chlorophenylboronic acid

(3-bromo-4-methoxy-phenyl)-methanol

3-(3’-chlorophenyl)-4-methoxybenzyl alcohol

Downstream raw materials:

[4-(3'-chloro-6-hydroxy-biphenyl-3-ylmethyl)-phenyl]-urea

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