Chemical Property of 4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine hydrochloride
Chemical Property:
- Melting Point:158 °C
- PSA：51.80000
- LogP:5.52470
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥20mg/mL
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:317.1095034
- Heavy Atom Count:22
- Complexity:349
- Purity/Quality:
-
97% *data from raw suppliers
RS-127445 hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25-36
- Safety Statements:
26-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N.Cl
-
Uses
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selec
tivity for this receptor as compared to numerous other receptor and ion channel binding sites. RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
