ACY-1215

Base Information

Chemical Name:ACY-1215
CAS No.:1316214-52-4
Molecular Formula:C24H27N5O3
Molecular Weight:433.51
Hs Code.:2933599090
Mol file:1316214-52-4.mol

Synonyms:N-[7-(Hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide;

Suppliers and Price of ACY-1215

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
ACY-1215
100mg
$ 232.00

American Custom Chemicals Corporation
ACY-1215 95.00%
5MG
$ 251.90

ApexBio Technology
Rocilinostat(ACY-1215)
50mg
$ 280.00

TRC
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
250mg
$ 275.00

DC Chemicals
Ricolinostat(ACY-1215) >98%
100 mg
$ 450.00

Crysdot
ACY-1215 98+%
100mg
$ 498.00

Crysdot
ACY-1215 98+%
50mg
$ 287.00

ChemScene
Ricolinostat 99.87%
5mg
$ 50.00

ChemScene
Ricolinostat 99.87%
10mg
$ 70.00

ChemScene
Ricolinostat 99.87%
50mg
$ 90.00

Total 53 raw suppliers

Chemical Property of ACY-1215

Chemical Property:

PKA:9.47±0.20(Predicted)
PSA：114.43000
Density:1.2±0.1 g/cm³
LogP:5.54720
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

ACY-1215 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.
Uses ACY-1215 acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).

Technology Process of ACY-1215

There total 11 articles about ACY-1215 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1316216-07-5
C₂₅H₂₈N₄O₃

: 1316214-52-4
N-[7-(hydroxyamino)-7-oxo-heptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

Guidance literature:: C₂₅H₂₈N₄O₃; With sodium hydroxide; In methanol; dichloromethane; at 0 ℃; for 0.166667h;

With hydroxylamine; In methanol; dichloromethane; water; at 0 - 20 ℃; for 0.333333h;

With hydrogenchloride; In water;

Reference yield:

: 89793-12-4
ethyl 2-chloropyrimidine-5-carboxylate

: 1316214-52-4
N-[7-(hydroxyamino)-7-oxo-heptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

2.1: caesium carbonate / copper(l) iodide / tetraethoxy orthosilicate / 14 h / 140 °C

3.1: water / ethanol / 0.5 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

5.1: sodium hydroxide / dichloromethane; methanol / 0.17 h / 0 °C

5.2: 0.33 h / 0 - 20 °C

With water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; copper(l) iodide; In tetrahydrofuran; methanol; tetraethoxy orthosilicate; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 62-53-3
aniline

: 1316214-52-4
N-[7-(hydroxyamino)-7-oxo-heptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

2.1: caesium carbonate / copper(l) iodide / tetraethoxy orthosilicate / 14 h / 140 °C

3.1: water / ethanol / 0.5 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

5.1: sodium hydroxide / dichloromethane; methanol / 0.17 h / 0 °C

5.2: 0.33 h / 0 - 20 °C

With water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; copper(l) iodide; In tetrahydrofuran; methanol; tetraethoxy orthosilicate; ethanol; dichloromethane; N,N-dimethyl-formamide;