BOC-(S)-2-METHOXY-PHENYLGLYCINE

Base Information

• Chemical Name: BOC-(S)-2-METHOXY-PHENYLGLYCINE
• CAS No.: 1217710-00-3
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Hs Code.: 2924299090
• Mol file: 1217710-00-3.mol

Synonyms:GL102-1;

Chemical Property of BOC-(S)-2-METHOXY-PHENYLGLYCINE

Chemical Property:

• PSA: 88.35000
• LogP: 2.55000
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

boc-(s)-2-methoxy-phenylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-(S)-2-METHOXY-PHENYLGLYCINE

There total 1 articles about BOC-(S)-2-METHOXY-PHENYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tert-butoxy-carbonylamino-(2-methoxy-phenyl)-acetic acid (179417-69-7,1217710-00-3)

Guidance literature:

With sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 24h;

Reference yield:

(S)-2-((tert-butoxycarbonyl)amino)-2-(2-methoxyphenyl)acetic acid. (1217710-00-3) → tert-butyl (S)-(2-amino-1-(2-methoxyphenyl)ethyl)carbamate

Guidance literature:

Multi-step reaction with 4 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; tetrahydrofuran / 3 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 60 °C

4: hydrogen; palladium 10% on activated carbon / ethanol; water / 0.33 h

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jmedchem.7b01861

Reference yield:

(S)-2-((tert-butoxycarbonyl)amino)-2-(2-methoxyphenyl)acetic acid. (1217710-00-3) → tert-butyl (S)-(2-azido-1-(2-methoxyphenyl)ethyl)carbamate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; tetrahydrofuran / 3 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 60 °C

With sodium azide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jmedchem.7b01861

Downstream raw materials:

methyl 2-(N-tert-butoxycarbonylamino)-2-(2-methoxylphenyl)acetate

Refernces

• 1、 -. "HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES". Paragraph 116; 117; 118. . Retrieved 2015/06/18.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 34. . Retrieved 2014/06/23.