[1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone

Base Information

Chemical Name:[1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
CAS No.:895155-25-6
Molecular Formula:C₂₃H₃₂N₂O
Molecular Weight:352.52
Hs Code.:
UNII:TPY5M47AYQ
ChEMBL ID:CHEMBL571330
DSSTox Substance ID:DTXSID001017492
Pharos Ligand ID:A9VURQ732T38
Wikipedia:AB-005
Mol file:895155-25-6.mol

Synonyms:895155-25-6;AB-005;TPY5M47AYQ;[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone;UNII-TPY5M47AYQ;CHEMBL571330;AB 005;(1-((1-Methyl-2-piperidinyl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone;Methanone, (1-((1-methyl-2-piperidinyl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-;[1-[(1-methyl-2-piperidinyl)methyl]-1h-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone;MOBWRRIAIHYXLB-UHFFFAOYSA-N;(1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone;{1-[(1-methylpiperidin-2-yl)methyl]-1h-indol-3-yl}(2,2,3,3-tetramethylcyclopropyl)methanone;SCHEMBL2078218;DTXSID001017492;EX-A3481;BDBM50303558;AC-36408;BM166976;NS00017427

Suppliers and Price of [1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AB-005
10mg
$ 100.00

Cayman Chemical
AB-005 ≥98%
1mg
$ 71.00

Cayman Chemical
AB-005 ≥98%
5mg
$ 317.00

Cayman Chemical
AB-005 ≥98%
10mg
$ 562.00

Biosynth Carbosynth
AB 005
50 mg
$ 375.00

Biosynth Carbosynth
AB 005
10 mg
$ 125.00

American Custom Chemicals Corporation
1-[(N-METHYLPIPERIDINE-2-YL)METHYL]-3-(2,2,3,3-TETRAMETHYLCYCLOPROPANE-1-CARBONYL)-1H-INDOLE 95.00%
5MG
$ 503.97

AK Scientific
[1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
10mg
$ 218.00

Total 13 raw suppliers

Chemical Property of [1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone

Chemical Property:

PSA：25.24000
LogP:4.92840
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:352.251463648
Heavy Atom Count:26
Complexity:540

Purity/Quality:

99%,98%, ^*data from raw suppliers

AB-005 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(C1(C)C)C(=O)C2=CN(C3=CC=CC=C32)CC4CCCCN4C)C
Uses AB-005 is a synthetic cannabinoid that is structurally related to AM-1241. AB-005 may potentially display increased selectivity towards CB2 receptor which is characteristic of cannabinoid containing the tetramethylcyclopropyl group.

Technology Process of [1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone

There total 5 articles about [1-[(1-Methylpiperidin-2-yl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 907160-87-6
(1-methylpiperidin-2-yl)methyl methanesulfonate

: 895155-25-6
(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: (1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h;

(1-methylpiperidin-2-yl)methyl methanesulfonate; In N,N-dimethyl-formamide; at 0 - 50 ℃; for 2h;

Reference yield:

: 895152-66-6
(1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

: 907160-87-6
(1-methylpiperidin-2-yl)methyl methanesulfonate

: 895155-25-6
(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: (1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

(1-methylpiperidin-2-yl)methyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 0 - 45 ℃;
DOI:10.1021/jm901214q

Reference yield:

: 20845-34-5
(1-methyl-piperidin-2-yl)-methanol

: 895155-25-6
(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0 - 23 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 0 - 45 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm901214q