(1S,3R)-3-Aminocyclohexanol

Base Information

• Chemical Name: (1S,3R)-3-Aminocyclohexanol
• CAS No.: 1110772-04-7
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Mol file: 1110772-04-7.mol

Synonyms:cis-3-aminocyclohexanol;

Chemical Property of (1S,3R)-3-Aminocyclohexanol

Chemical Property:

• Boiling Point: 201.1±33.0 °C(Predicted)
• PKA: 15.09±0.40(Predicted)
• PSA: 46.25000
• Density: 1.037±0.06 g/cm3(Predicted)
• LogP: 0.94890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

(1S,3R)-3-Amino-cyclohexanol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,3R)-3-Aminocyclohexanol

There total 10 articles about (1S,3R)-3-Aminocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3S)-2-(3-hydroxycyclohexyl)isoindole-1,3-dione → 2,3-dihydrophthalazine-1,4-dione (1445-69-8) + (1S,3R)-3-aminocyclohexan-1-ol (1110772-04-7)

Guidance literature:

With hydrazine hydrate;

DOI:10.1016/j.bmcl.2010.12.092

Reference yield:

(1S,3R)-2-(3-hydroxycyclohexyl)isoindole-1,3-dione → (1S,3R)-3-aminocyclohexan-1-ol (1110772-04-7)

Guidance literature:

With hydrazine; In ethanol; at 100 ℃; for 3h;

Reference yield:

((1R,3S)-3-hydroxycyclohexyl)carbamic acid benzyl ester (750649-39-9,750649-44-6) → (1S,3R)-3-aminocyclohexan-1-ol (1110772-04-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 760.051 Torr; optical yield given as %ee;

DOI:10.1016/j.bmcl.2010.12.092

upstream raw materials:

((1R,3S)-3-hydroxycyclohexyl)carbamic acid benzyl ester

rac-3-bromocyclohexene

2-cyclohex-2-enyl-isoindole-1,3-dione

cis-2-(3-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

((1R,3S)-3-hydroxycyclohexyl)carbamic acid benzyl ester

(1S,3R)-3-(dibenzylamino)cyclohexanol

tert-butyl (1R,3S)-3-hydroxycyclohexylcarbamate

(R)-3-(dibenzylamino)cyclohexanone