CHR-6494

Base Information

• Chemical Name: CHR-6494
• CAS No.: 1333377-65-3
• Molecular Formula: C16H16N6
• Molecular Weight: 292.33844
• Mol file: 1333377-65-3.mol

Synonyms:CHR-6494;3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;CHR-6494 3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine

Chemical Property of CHR-6494

Chemical Property:

• PKA: 13.24±0.40(Predicted)
• PSA: 74.13000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 2.51640
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

98% min ^*data from raw suppliers

Haspin Kinase Inhibitor, CHR-6494 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 μM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph). CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2/M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model.
• Uses: CHR6494 is a small-molecule inhibitor of histone kinase haspin, with a wide spectrum of anticancer effects.