ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE
• CAS No.: 80812-55-1
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Hs Code.: 2933990090
• Mol file: 80812-55-1.mol

Synonyms:ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate;HMS2504J07;

Chemical Property of ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE

Chemical Property:

• Melting Point: 260 °C(Solv: methanol (67-56-1))
• Boiling Point: 476.3±45.0 °C(Predicted)
• PKA: 11.60±0.20(Predicted)
• PSA: 72.31000
• Density: 1.248±0.06 g/cm3(Predicted)
• LogP: 1.82050

Purity/Quality:

97% ^*data from raw suppliers

ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE

There total 4 articles about ETHYL 2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,3,5-Triazine (290-87-9) + 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester (1149-24-2) → ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate (80812-55-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570260644

Reference yield: 64.3%

diethyl 2-<2-(N,N-dimethylamino)vinyl>-6-methylpyridine-3,5-dicarboxylate (80823-75-2) → ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate (80812-55-1)

Guidance literature:

With ammonium hydroxide; In ethanol; for 36h; Ambient temperature;

Reference yield:

triethyl 2,7,8a-trimethyl-1,4,4a,5,8,8a-hexahydro-1,8-naphthyridine-3,4a,6-tricarboxylate (107293-12-9) → ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate (80812-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / acetic acid / 0.5 h / 100 °C

2: 55.5 percent / NaOEt / ethanol / 2 h / Heating

With sodium ethanolate; acetic acid; In ethanol;

upstream raw materials:

1,3,5-Triazine

2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester

diethyl 2-<2-(N,N-dimethylamino)vinyl>-6-methylpyridine-3,5-dicarboxylate

triethyl 2,7,8a-trimethyl-1,4,4a,5,8,8a-hexahydro-1,8-naphthyridine-3,4a,6-tricarboxylate