(S)-1-(Thiazol-2-YL)ethanamine

Base Information

• Chemical Name: (S)-1-(Thiazol-2-YL)ethanamine
• CAS No.: 623143-42-0
• Molecular Formula: C5H8N2S
• Molecular Weight: 164.65636
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID701292651
• Mol file: 623143-42-0.mol

Synonyms:623143-42-0;(S)-1-(THIAZOL-2-YL)ETHANAMINE;(1S)-1-(1,3-thiazol-2-yl)ethanamine;(1S)-1-(1,3-thiazol-2-yl)ethan-1-amine;(S)-1-(thiazol-2-yl)ethan-1-amine;SCHEMBL3342146;DUOLTCNKKZZNIC-BYPYZUCNSA-N;DTXSID701292651;YZA14342;MFCD13184144;AKOS016352939;AC-29372;NS-01041;(alphaS)-alpha-Methyl-2-thiazolemethanamine;CS-0266734;(1S)-1-(1,3-thiazol-2-yl)-1-ethylamine;EN300-85187;A868509

Chemical Property of (S)-1-(Thiazol-2-YL)ethanamine

Chemical Property:

• Boiling Point: 185.3±23.0 °C(Predicted)
• PKA: 7.30±0.40(Predicted)
• PSA: 67.15000
• Density: 1.172±0.06 g/cm3(Predicted)
• LogP: 2.66510
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 128.04081944
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

98% ^*data from raw suppliers

(S)-1-(Thiazol-2-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=NC=CS1)N
• Isomeric SMILES: C[C@@H](C1=NC=CS1)N

Technology Process of (S)-1-(Thiazol-2-YL)ethanamine

There total 5 articles about (S)-1-(Thiazol-2-YL)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(1-aminoethyl)thiazole hydrochloride (1427063-33-9,2323582-65-4,947662-64-8) → (1S)-1-(1,3-thiazol-2-yl)ethanamine (623143-42-0)

Guidance literature:

With sodium methylate; In methanol; dichloromethane; at 25 ℃; for 1.5h;

Reference yield:

C9H16N2OS2 (1207362-94-4) → (1S)-1-(1,3-thiazol-2-yl)ethanamine (623143-42-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 0 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/asia.201100338

Reference yield:

2-Acetylthiazole (24295-03-2,260998-74-1) → (1S)-1-(1,3-thiazol-2-yl)ethanamine (623143-42-0)

Guidance literature:

With pyridoxal 5'-phosphate; isopropylamine; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1021/op4003104

upstream raw materials:

(S)-2-(1'-N-tert-butoxycarbonylaminoethyl)thiazole

(S)-2-(1-aminoethyl)thiazole hydrochloride

C₉H₁₆N₂OS₂

2-Acetylthiazole

Downstream raw materials:

dysidenin

Refernces

• 1、 Ilardi, Elizabeth A.,Zakarian, Armen. "Efficient total synthesis of dysidenin, dysidin, and barbamide". supporting information; experimental part. p. 2260 - 2263. Retrieved 2012/06/30.
• 2、 Miyazaki,Kobayashi,Natsume,Gondo,Mikami,Sakakibara,Tsukagoshi. "Synthesis and antitumor activity of novel dolastatin 10 analogs". . p. 1706 - 1718. Retrieved 2007/10/03.