7-broMo-3,4-dihydro-2(1H)-Quinoxalinone

Base Information

• Chemical Name: 7-broMo-3,4-dihydro-2(1H)-Quinoxalinone
• CAS No.: 1016878-52-6
• Molecular Formula: C8H7BrN2O
• Molecular Weight: 227.06
• Hs Code.: 2933990090
• Mol file: 1016878-52-6.mol

Synonyms:7-Bromo-1,2,3,4-tetrahydroquinoxalin-2-one;7-Bromo-3,4-dihydro-2(1H)-quinoxalinone;

Chemical Property of 7-broMo-3,4-dihydro-2(1H)-Quinoxalinone

Chemical Property:

• Boiling Point: 400.101 °C at 760 mmHg
• Flash Point: 195.774 °C
• PSA: 44.62000
• Density: 1.61 g/cm³
• LogP: 2.03620
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-3,4-dihydroquinoxalin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-broMo-3,4-dihydro-2(1H)-Quinoxalinone

There total 2 articles about 7-broMo-3,4-dihydro-2(1H)-Quinoxalinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

methyl (4-bromo-2-nitrophenyl)glycinate → 7-bromo-3,4-dihydroquinoxalin-2(1H)-one (1016878-52-6)

Guidance literature:

With acetic acid;

Reference yield:

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → 7-bromo-3,4-dihydroquinoxalin-2(1H)-one (1016878-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: acetic acid; iron / Reflux

With iron; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.0c02953

Reference yield:

7-bromo-3,4-dihydroquinoxalin-2(1H)-one (1016878-52-6) → tert-butyl 6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate

Guidance literature:

Multi-step reaction with 4 steps

1: dmap

3: dmap

4: sodium carbonate

With dmap; sodium carbonate;

upstream raw materials:

4-Bromo-1-fluoro-2-nitrobenzene

Downstream raw materials:

4-((6bR,10aS)-5-bromo-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

Refernces

• 1、 Rostoll-Berenguer, Jaume,Blay, Gonzalo,Pedro, José R.,Vila, Carlos. "Photocatalytic Giese Addition of 1,4-Dihydroquinoxalin-2-ones to Electron-Poor Alkenes Using Visible Light". supporting information. p. 8012 - 8017. Retrieved 2020/11/02.