(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide

Base Information

Chemical Name:(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide
CAS No.:1258327-08-0
Molecular Formula:C₃₇H₂₇O₄P
Molecular Weight:566.593
Hs Code.:
Mol file:1258327-08-0.mol

Synonyms:(11aS)-5-oxide-10,11,12,13-tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin;(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide;(11aS)-10,11,12,13-Ttetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin;(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1- naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2] dioxaphosphocin;Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin, 10,11,12,13-tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-, 5-oxide, (11aS)-;(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin,99%e.e.;(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg] [1,3,2]dioxaphosphocin 98% (99% ee)

Suppliers and Price of (11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Strem Chemicals
(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg] [1,3,2]dioxaphosphocin 98% (99% ee) 2]dioxaphosphocin 98% (99% ee)
50mg
$ 225.00

Total 6 raw suppliers

Chemical Property of (11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide

Chemical Property:

Melting Point:>300℃
PSA：65.57000
Density:1.44
LogP:9.37710

Purity/Quality:

99% ^*data from raw suppliers

(11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-5-oxide-diindeno[7,1-de:1',7'-fg] [1,3,2]dioxaphosphocin 98% (99% ee) 2]dioxaphosphocin 98% (99% ee) ^*data from reagent suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of (11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide

There total 5 articles about (11aS)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-di-1-naphthalenyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292849-40-1
(S)-6,6'-di(naphthalen-1-yl)-1,1'-spirobiindane-7,7'-diol

: 1258327-08-0,1297613-73-0
(S)-6,6-di(naphthalen-1-yl)-1,1'-spirobiindane-7,7'-diyl phosphate

Guidance literature:: (S)-6,6'-di(naphthalen-1-yl)-1,1'-spirobiindane-7,7'-diol; With pyridine; trichlorophosphate; at 0 - 70 ℃; for 3h; Inert atmosphere;

With water; at 0 - 110 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo101640z

Reference yield:

: (S)-7,7'-bis(1-methoxymethoxy)-1,1'-spirobiindane

: 1258327-08-0,1297613-73-0
(S)-6,6-di(naphthalen-1-yl)-1,1'-spirobiindane-7,7'-diyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 6 h / -78 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; chloroform; water / 3 h / Inert atmosphere; Reflux

3.1: 5% Pd(II)/C(eggshell); potassium carbonate / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

4.1: pyridine; trichlorophosphate / 3 h / 0 - 70 °C / Inert atmosphere

4.2: 4 h / 0 - 110 °C / Inert atmosphere

With pyridine; hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 5% Pd(II)/C(eggshell); potassium carbonate; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether; hexane; chloroform; water; 3.1: Suzuki coupling;
DOI:10.1021/jo101640z

Reference yield:

: (S)-6,6'-diiodo-7,7'-bis(methoxymethoxy)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]

: 1258327-08-0,1297613-73-0
(S)-6,6-di(naphthalen-1-yl)-1,1'-spirobiindane-7,7'-diyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; chloroform; water / 3 h / Inert atmosphere; Reflux

2.1: 5% Pd(II)/C(eggshell); potassium carbonate / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

3.1: pyridine; trichlorophosphate / 3 h / 0 - 70 °C / Inert atmosphere

3.2: 4 h / 0 - 110 °C / Inert atmosphere

With pyridine; hydrogenchloride; 5% Pd(II)/C(eggshell); potassium carbonate; trichlorophosphate; In 1,4-dioxane; methanol; chloroform; water; 2.1: Suzuki coupling;
DOI:10.1021/jo101640z