THIOLACTOMYCIN

Base Information

Chemical Name:THIOLACTOMYCIN
CAS No.:82079-32-1
Molecular Formula:C11H14O2S
Molecular Weight:210.297
Hs Code.:
Mol file:82079-32-1.mol

Synonyms:[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone;2(5H)-Thiophenone,3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-,(R-(E));Antibiotic 2-200;TLM;(+)-Thiolactomycin;(R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one;(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone;(5R)-4-hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5-H-thiophen-2-one;(R)-(+)-Thiolactomycin;5R-Thiolactomycin;

Suppliers and Price of THIOLACTOMYCIN

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-Thiolactomycin
10mg
$ 1390.00

TRC
(R)-(+)-Thiolactomycin
1mg
$ 180.00

Medical Isotopes, Inc.
(R)-(+)-Thiolactomycin
25 mg
$ 2200.00

American Custom Chemicals Corporation
THIOLACTOMYCIN 95.00%
5MG
$ 505.45

Total 10 raw suppliers

Chemical Property of THIOLACTOMYCIN

Chemical Property:

Vapor Pressure:2.83E-05mmHg at 25°C
Boiling Point:319.2°Cat760mmHg
Flash Point:146.8°C
PSA：62.60000
Density:1.214g/cm³
LogP:2.98280
Solubility.:DMSO: ~21 mg/mL, soluble

Purity/Quality:

99% ^*data from raw suppliers

(R)-(+)-Thiolactomycin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-(+)-Thiolactomycin is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).

Technology Process of THIOLACTOMYCIN

There total 20 articles about THIOLACTOMYCIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 913941-71-6
(R)-4-Methoxy-3,5-dimethyl-5-((E)-2-methyl-buta-1,3-dienyl)-5H-thiophen-2-one

: 82079-32-1
(+)-thiolactomycin

Guidance literature:: With lithium n-propylmercaptide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2006.07.152

Reference yield: 80.0%

: 476371-89-8
(2R)-2,4-dimethyl-2-thiopropionyl-hexa-3,5-dienoic acid ethyl ester

: 82079-32-1
(+)-thiolactomycin

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -5 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00236