bicyclo[1.1.1]pentan-1-aMine

Base Information

• Chemical Name: bicyclo[1.1.1]pentan-1-aMine
• CAS No.: 22287-35-0
• Molecular Formula: C5H9N.ClH
• Molecular Weight: 119.594
• Hs Code.: 2921300090
• Mol file: 22287-35-0.mol

Synonyms:bicyclo[1.1.1]pent-1-ylamine hydrochloride; 1-Bicyclo<1.1.1>pentylamin-Hydrochlorid; 1-aminobicyclo<1.1.1>pentane hydrochloride; bicyclo[1.1.1]-pentan-1-amine hydrochloride; 1-bicyclo[1.1.1]pentylamine hydrochloride

Chemical Property of bicyclo[1.1.1]pentan-1-aMine

Chemical Property:

• Melting Point: 242-244 °C
• PSA: 26.02000
• LogP: 1.99990
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

97% ^*data from raw suppliers

Bicyclo[1.1.1]pentan-1-amine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bicyclo[1.1.1]pentylamine hydrochloride can be used to synthesize bisbicyclo[1.1.1]pentyldiazene.It is used as a precursor in the synthesis of a potent quinolone antibacterial agent, U-87947E.It can also be used to prepare bicyclo[1.1.1]pentane-derived azides for click chemistry applications.

Technology Process of bicyclo[1.1.1]pentan-1-aMine

There total 6 articles about bicyclo[1.1.1]pentan-1-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

bicyclo[1.1.1]pentan-1-ylhydrazine hydrochloric acid salt → 1-aminobicyclo<1.1.1>pentane hydrochloride (22287-35-0)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 20h;

Reference yield: 80.0%

bicyclo[1.1.1]pentan-1-ylhydrazine hydrochloride → 1-aminobicyclo<1.1.1>pentane hydrochloride (22287-35-0)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; at 25 ℃; for 24h; under 2250.23 Torr;

DOI:10.1021/ol201883z

Reference yield: 16.0%

1-azido-3-iodobicyclo<1.1.1>pentane (136863-38-2) → 1-aminobicyclo<1.1.1>pentane hydrochloride (22287-35-0)

Guidance literature:

With hydrogenchloride; 20 wt.% Pd(OH)2 on activated carbon; hydrogen; In methanol; at 20 ℃; for 36h; under 6000.6 Torr;

DOI:10.1021/ol201883z

upstream raw materials:

1-azido-3-iodobicyclo<1.1.1>pentane

biclyclo [1.1.1]pentyl-1-azide

bicyclo[1.1.1]pentane-1-carboxylic acid

Downstream raw materials:

Imidazole-1-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

ethyl 4-(bicyclo[1.1.1]pentan-1-ylamino)-2-(methylthio)pyrimidine-5-carboxylate

2-(bicyclo[1.1.1]pentan-1-ylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)pyrimidine-5-carbonitrile