3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester
• CAS No.: 1217710-80-9
• Molecular Formula: C15H28N2O4
• Molecular Weight: 300.39382
• Hs Code.: 2933399090
• Mol file: 1217710-80-9.mol

Synonyms:3-(((tert-butoxy)carbonyl)amino)-1-piperidinecarboxylic acid tert-butyl ester

Chemical Property of 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 397.5±31.0 °C(Predicted)
• PKA: 12.26±0.20(Predicted)
• PSA: 71.36000
• Density: 1.07
• LogP: 3.05290
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate, is a building block used in chemical synthesis.

Technology Process of 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester

There total 7 articles about 3-[[(tert-Butoxy)carbonyl]amino]-1-piperidinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C16H28N2O6 → tert-butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (1217710-80-9,1263078-12-1,1282440-46-3)

Guidance literature:

With caesium carbonate; In acetonitrile; at 100 ℃; for 5h; Sealed tube;

DOI:10.1021/acs.joc.8b00970

Reference yield:

(3R)-3-azido-1-[(1R)-1-phenylethyl]piperidine → N,N'-di-tert-butoxycarbonyl-(3R)-3-aminopiperidine (1217710-80-9,1263078-12-1,1282440-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium(II) hydroxide; hydrogen / ethanol / 1 h / 20 °C / 760.05 Torr

2: ethanol / 1 h / 20 °C / Inert atmosphere

With hydrogen; palladium(II) hydroxide; In ethanol;

DOI:10.1002/asia.201301551

Reference yield:

methyl 3-[(1R)-1-phenylethylaziridin-2-yl]propanoate → N,N'-di-tert-butoxycarbonyl-(3R)-3-aminopiperidine (1217710-80-9,1263078-12-1,1282440-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

3: sodium azide / acetonitrile / 24 h / 20 °C / Inert atmosphere

4: palladium(II) hydroxide; hydrogen / ethanol / 1 h / 20 °C / 760.05 Torr

5: ethanol / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium azide; hydrogen; palladium(II) hydroxide; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1002/asia.201301551

upstream raw materials:

(R)-piperidin-3-ylamine

di-tert-butyl dicarbonate