CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Base Information

• Chemical Name: CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE
• CAS No.: 1067631-21-3
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32
• Mol file: 1067631-21-3.mol

Synonyms:CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Chemical Property of CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Chemical Property:

• PSA: 64.35000
• LogP: 3.27390

Purity/Quality:

97% ^*data from raw suppliers

BenzylN-(2-aminocyclohexyl)carbamate;oxalicacid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

There total 10 articles about CIS-(1S,2R)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R)-1-(N-benzyloxycarbonylamino)-2-phthalimidocyclohexane (957060-27-4) → benzyl N-[(1S,2R)-2-aminocyclohexyl]carbamate (1067631-21-3,1353973-30-4,445479-92-5)

Guidance literature:

With hydrazine; In methanol; for 10h; Heating;

DOI:10.1016/j.tetasy.2007.08.014

Reference yield:

(1S,2R)-2-phthalimidocyclohexanecarboxylic acid (957060-24-1) → benzyl N-[(1S,2R)-2-aminocyclohexyl]carbamate (1067631-21-3,1353973-30-4,445479-92-5)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride; dimethylformamide / CH₂Cl₂ / 1 h / 20 °C

2: NaN₃ / acetone / 0.17 h / 0 °C

3: toluene / 1 h / Heating

4: 108.8 mg / toluene / 27 h / Heating

5: NH₂NH₂ / methanol / 10 h / Heating

With thionyl chloride; sodium azide; N,N-dimethyl-formamide; hydrazine; In methanol; dichloromethane; acetone; toluene; 3: Curtius rearrangement;

DOI:10.1016/j.tetasy.2007.08.014

Reference yield:

C15H14ClNO3 → benzyl N-[(1S,2R)-2-aminocyclohexyl]carbamate (1067631-21-3,1353973-30-4,445479-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: NaN₃ / acetone / 0.17 h / 0 °C

2: toluene / 1 h / Heating

3: 108.8 mg / toluene / 27 h / Heating

4: NH₂NH₂ / methanol / 10 h / Heating

With sodium azide; hydrazine; In methanol; acetone; toluene; 2: Curtius rearrangement;

DOI:10.1016/j.tetasy.2007.08.014

upstream raw materials:

(1S,2R)-1-(N-benzyloxycarbonylamino)-2-phthalimidocyclohexane

(1S,2R)-2-phthalimidocyclohexanecarboxylic acid

C₁₅H₁₄N₄O₃

benzyl 2-oxocyclohexanecarboxylate

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