(2-Chloropyridin-4-yl)methanamine hydrochloride

Base Information

• Chemical Name: (2-Chloropyridin-4-yl)methanamine hydrochloride
• CAS No.: 916210-98-5
• Molecular Formula: C₆H₇ClN₂*ClH
• Molecular Weight: 179.049
• Hs Code.: 2933399090
• Mol file: 916210-98-5.mol

Synonyms:(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

Chemical Property of (2-Chloropyridin-4-yl)methanamine hydrochloride

Chemical Property:

• PSA: 38.91000
• LogP: 2.69600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Chloropyridin-4-yl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Chloropyridin-4-yl)methanamine hydrochloride

There total 1 articles about (2-Chloropyridin-4-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-chloro-4-pyridinenitrile (33252-30-1) → 1-(2-chloropyridin-4-yl)methanamine hydrochloride (916210-98-5)

Guidance literature:

2-chloro-4-pyridinenitrile; With fac-[Mn(1,2-bis(di-n-propylphosphino)ethane)(CO)₃(CH₃)]; hydrogen; In toluene; at 100 ℃; for 18h; under 37503.8 Torr; Autoclave;

With hydrogenchloride; In diethyl ether; Inert atmosphere;

DOI:10.1002/adsc.201901040

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (2-chloropyridin-4-yl)methanamine bishydrochloride (916210-98-5) → tert-butyl N-[(2-chloro-4-pyridyl) methyl]carbamate (916210-27-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

2-chloro-4-pyridinenitrile

Downstream raw materials:

tert-butyl N-[(2-chloro-4-pyridyl) methyl]carbamate

Refernces