2-(4-(2-(TrifluoroMethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid

Base Information

• Chemical Name: 2-(4-(2-(TrifluoroMethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid
• CAS No.: 916888-64-7
• Molecular Formula: C16H14 F3 N3O3S
• Molecular Weight: 385.367
• Hs Code.: 2934100090
• Mol file: 916888-64-7.mol

Synonyms:2-{4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid;2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid;

Chemical Property of 2-(4-(2-(TrifluoroMethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid

Chemical Property:

• PSA: 101.98000
• LogP: 2.82540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(2-(TrifluoroMethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid

There total 4 articles about 2-(4-(2-(TrifluoroMethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]thiazole-5-carboxylic acid methyl ester (881384-32-3) → 2-{4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid (916888-64-7)

Guidance literature:

2-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]thiazole-5-carboxylic acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; at 50 ℃; for 5h;

With hydrogenchloride; In water; pH=1;

Reference yield:

4-(2-trifluoromethylbenzoyl)piperazine-1-carboxylic acid t-butyl ester (840491-84-1) → 2-{4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid (916888-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 5 h / 80 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 50 °C

3.2: pH 1

With sodium hydroxide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

piperazine-1-yl-(2-trifluoromethylphenyl)methanone (179534-78-2) → 2-{4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid (916888-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 5 h / 80 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 50 °C

2.2: pH 1

With sodium hydroxide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

upstream raw materials:

2-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]thiazole-5-carboxylic acid methyl ester

4-(2-trifluoromethylbenzoyl)piperazine-1-carboxylic acid t-butyl ester

piperazine-1-yl-(2-trifluoromethylphenyl)methanone

2-trifluoromethylbenzoyl chloride

Downstream raw materials:

MF-152