1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

Base Information

• Chemical Name: 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine
• CAS No.: 401566-79-8
• Molecular Formula: C14H18 N4
• Molecular Weight: 242.32
• Hs Code.: 2933990090
• Mol file: 401566-79-8.mol

Synonyms:1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

Chemical Property of 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

Chemical Property:

• Boiling Point: 429℃
• PKA: 8.90±0.10(Predicted)
• Flash Point: 213℃
• PSA: 33.09000
• Density: 1.19
• LogP: 1.98410
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.

Technology Process of 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

There total 17 articles about 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

1-tert-butoxycarbonyl-4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine (401566-79-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2019.112017

Reference yield: 92.0%

5-(4-N-benzyl-N-piperazino)-3-methyl-1-phenyl-1H-pyrazole → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine (401566-79-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 30 - 60 ℃; for 8h; Autoclave; Large scale;

DOI:10.1080/00304948.2020.1858688

Reference yield: 88.0%

ethyl 4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine-1-carboxylate → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine (401566-79-8)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; for 4h; Reflux; Large scale;

DOI:10.1080/00304948.2020.1858688

upstream raw materials:

1-Phenyl-3-methyl-5-aminopyrazole

bis-(2-chloroethyl)amine hydrochloride

iodobenzene

3-methyl-1-phenylpyrazolin-5(4H)-one

Downstream raw materials:

C₂₂H₃₀N₆OS