(R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID

Base Information

Chemical Name:(R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID
CAS No.:78444-90-3
Molecular Formula:C11H18N2O5
Molecular Weight:258.274
Hs Code.:
Mol file:78444-90-3.mol

Synonyms:(R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID;3(R)-[N-(tert-butoxycarbonyl)amino]-2-oxo-1-pyrrolidineacetic acid;3(R)-[(tert-butyloxycarbonyl)amino]-2-oxo-1-pyrrolidineacetic acid;

Suppliers and Price of (R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-oxo-1-pyrrolidineaceticAcid
10mg
$ 75.00

Crysdot
(R)-3-(Boc-amino)-2-oxo-1-pyrrolidine-aceticacid 95+%
1g
$ 706.00

Chemenu
(R)-3-(Boc-amino)-2-oxo-1-pyrrolidine-aceticacid 95%
1g
$ 667.00

AK Scientific
(R)-3-(Boc-amino)-2-oxo-1-pyrrolidine-aceticacid
1g
$ 602.00

Total 5 raw suppliers

Chemical Property of (R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID

Chemical Property:

PSA：95.94000
LogP:0.52540

Purity/Quality:

≥ 99% (NMR) ^*data from raw suppliers

(3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-oxo-1-pyrrolidineaceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-oxo-1-pyrrolidineacetic Acid is used as a reactant in the synthesis of peptide mimics.

Technology Process of (R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID

There total 1 articles about (R)-3-(BOC-AMINO)-2-OXO-1-PYRROLIDINE-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: [(R)-3-tert-Butoxycarbonylamino-3-(methoxycarbonylmethyl-carbamoyl)-propyl]-dimethyl-sulfonium; iodide

: 78444-90-3,116339-45-8
(R)-3-<(tert-butyloxycarbonyl)amino>-2-oxo-1-pyrrolidineacetic acid

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1) 4 deg C, 5 min; 2) room temperature, 15 min;
DOI:10.1021/jm00402a031

Reference yield: 90.0%

: 18807-71-1
benzyl N-(2-aminoethyl)carbamate hydrochloride

: 78444-90-3,116339-45-8
(R)-3-<(tert-butyloxycarbonyl)amino>-2-oxo-1-pyrrolidineacetic acid

: N-[((2-benzyloxycarbonylamino)ethylcarbamoyl)methyl]-3(R)-[N-(tert-butoxycarbonyl)amino]pyrrolidin-2-one

Guidance literature:: (R)-3-<(tert-butyloxycarbonyl)amino>-2-oxo-1-pyrrolidineacetic acid; With N-methylcyclohexylamine; isobutyl chloroformate; In tetrahydrofuran; at -23 ℃; for 0.166667h;

With benzotriazol-1-ol; In tetrahydrofuran; at -23 ℃; for 0.166667h;

benzyl N-(2-aminoethyl)carbamate hydrochloride; With N-methylcyclohexylamine; In tetrahydrofuran; at -23 - 20 ℃;
DOI:10.1021/jm050644n

Reference yield:

: 78444-90-3,116339-45-8
(R)-3-<(tert-butyloxycarbonyl)amino>-2-oxo-1-pyrrolidineacetic acid

: {2-[2-((R)-3-Amino-2-oxo-pyrrolidin-1-yl)-acetylamino]-ethyl}-carbamic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylpiperidine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -23 °C

1.2: HOBt / tetrahydrofuran / 0.17 h / -23 °C

1.3: 90 percent / N-methylpiperidine / tetrahydrofuran / -23 - 20 °C

2.1: CH₂Cl₂ / 20 °C

With N-methylcyclohexylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050644n