R-3,3'-Bis(4-(1,1-diMethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate

Base Information

• Chemical Name: R-3,3'-Bis(4-(1,1-diMethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate
• CAS No.: 861909-30-0
• Molecular Formula: C₄₀H₃₇O₄P
• Molecular Weight: 612.705
• Mol file: 861909-30-0.mol

Synonyms:(R)-3,3'-Bis(4-(1,1-dimethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl Hydrogen Phosphate;

Chemical Property of R-3,3'-Bis(4-(1,1-diMethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate

Chemical Property:

• Boiling Point: 765.6±70.0 °C(Predicted)
• PKA: 1.12±0.20(Predicted)
• PSA: 65.57000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 11.46060
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(11bR)-2,6-Bis[4-(1,1-dimethylethyl)phenyl]-4-hydroxy-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin, 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-3,3'-Bis(4-(1,1-diMethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate

There total 12 articles about R-3,3'-Bis(4-(1,1-diMethylethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(Ra)-2,6-bis(4-(tert-butyl)phenyl)-4-chlorodinaphtho[1,3,2]dioxaphosphepine 4-oxide → (R)-3,3’-bis(4-t-butylphenyl)-[1,1’-binaphthalene]-2,2’-diyl hydrogen phosphate (1217901-32-0,861909-30-0)

Guidance literature:

With pyridine; In water; at 100 ℃; Inert atmosphere;

DOI:10.1002/anie.201303527

Reference yield: 95.0%

(R)-3,3'-dibromo-1,1'-binaphthalene-2,2'-diyl phosphoric acid (861909-33-3,1644121-35-6) + p-tert-butylphenylboronic acid (123324-71-0) → (R)-3,3’-bis(4-t-butylphenyl)-[1,1’-binaphthalene]-2,2’-diyl hydrogen phosphate (1217901-32-0,861909-30-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,2-dimethoxyethane; at 85 ℃; for 48h; Inert atmosphere;

DOI:10.1002/ejoc.201100328

Reference yield: 94.0%

(Ra)-3,3’-bis(4-(tert-butyl)phenyl)[1,1’-binaphthalene]-2,2’-diol → (R)-3,3’-bis(4-t-butylphenyl)-[1,1’-binaphthalene]-2,2’-diyl hydrogen phosphate (1217901-32-0,861909-30-0)

Guidance literature:

(R_a)-3,3’-bis(4-(tert-butyl)phenyl)[1,1’-binaphthalene]-2,2’-diol; With pyridine; trichlorophosphate; at 20 - 90 ℃; for 2.16667h; Inert atmosphere;

With water; at 90 ℃; for 2h;

DOI:10.1021/jacs.6b11198

upstream raw materials:

(R)-3,3'-dibromo-1,1'-binaphthalene-2,2'-diyl phosphoric acid

p-tert-butylphenylboronic acid

(R)-2,2'-dimethoxy-1,1'-dinaphthyl

(R)-1,1'-Bi-2-naphthol