N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea

Base Information

Chemical Name:N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea
CAS No.:866940-63-8
Molecular Formula:C₃₁H₂₃F₆N₃S
Molecular Weight:583.6
Hs Code.:
Mol file:866940-63-8.mol

Synonyms:(S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea;N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(R)-2'- (dimethylamino)[1,1'-binaphthalen]-2-yl]thiourea;N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea;Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(1R)-2'-(dimethylamino)[1,1'-binaphthalen]-2-yl]-;N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(R)-2'- (dimethylamino)[1,1'-binaphthalen]-2-yl]thiourea,99%e.e.

Suppliers and Price of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea 95+%
1g
$ 1965.00

ChemScene
N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(R)-2'-(dimethylamino)[1,1'-binaphthalen]-2-yl]thiourea ≥97.0%
100mg
$ 156.00

Alichem
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea
1g
$ 2019.60

Total 10 raw suppliers

Chemical Property of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea

Chemical Property:

Boiling Point:596.8±60.0 °C(Predicted)
PKA:11.27±0.70(Predicted)
PSA：59.39000
Density:1.402±0.06 g/cm3(Predicted)
LogP:9.71850

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea

There total 3 articles about N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R)-2'-(diMethylaMino)[1,1'-binaphthalen]-2-yl]- Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: (R)-1-(2-(dimethylamino)naphthalen-1-yl)naphthalen-2-amine

: 866940-63-8
(R)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-(2-(dimethylamino)naphthalen-1-yl)naphthalen-2-yl)thiourea

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol051822+

Reference yield: 36.0%

: 866940-63-8
(R)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-(2-(dimethylamino)naphthalen-1-yl)naphthalen-2-yl)thiourea

Guidance literature:: With hydrogenchloride; In ethanol; at 120 ℃; for 3h;

In tetrahydrofuran; for 1h; Inert atmosphere;

Reference yield:

: (R)-N-(1-(2-(dimethylamino)naphthalen-1-yl)naphthalen-2-yl)acetamide

: 866940-63-8
(R)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(1-(2-(dimethylamino)naphthalen-1-yl)naphthalen-2-yl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / aq. HCl / ethanol / 20 °C

2: 91 percent / CH₂Cl₂ / 20 °C

With hydrogenchloride; In ethanol; dichloromethane;
DOI:10.1021/ol0519137