N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Base Information

Chemical Name:N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
CAS No.:1027476-96-5
Molecular Formula:C15 H17 F6 N3 S
Molecular Weight:385.3709992
Hs Code.:
Mol file:1027476-96-5.mol

Synonyms:1-((1S,2S)-2-Aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea;N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea;Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]-;N-[(1S,2S)-2-Aminocyclohexyl]-N'-[3,5- bis(trifluoromethyl)phenyl]thiourea,99%e.e.;N-[(1S,2S)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea, 98%, (99% ee)

Suppliers and Price of N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
N-[(1S,2S)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea, 98%, (99% ee) (99% ee)
100mg
$ 87.00

ChemScene
N-[(1S,2S)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea
100mg
$ 116.00

Total 9 raw suppliers

Chemical Property of N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Chemical Property:

Boiling Point:364.5±52.0 °C(Predicted)
PKA:11.76±0.70(Predicted)
PSA：82.17000
Density:1.40±0.1 g/cm3(Predicted)
LogP:5.44470

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-[(1S,2S)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea, 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

There total 1 articles about N-[(1S,2S)-2-aMinocyclohexyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21436-03-3
(S,S)-1,2-diaminocyclohexane

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1027476-96-5
N-((1S,2S)-2-aminocyclohexyl)-N'-(3,5-bis(trifluoromethyl)phenyl)thiourea

Guidance literature:: In dichloromethane; at 0 ℃; for 20h;
DOI:10.3998/ark.5550190.0011.229

Reference yield: 62.0%

: 1027476-96-5
N-((1S,2S)-2-aminocyclohexyl)-N'-(3,5-bis(trifluoromethyl)phenyl)thiourea

: N-((3aS,7aS)-hexahydro-1H-benzo[d]imidazol-2(3H)-ylidene)-3,5-bis(trifluoromethyl)aniline

Guidance literature:: With thiourea; dicyclohexyl-carbodiimide; In toluene; for 24h; Reflux;
DOI:10.1021/acs.joc.0c01917

Reference yield:

: 1027476-96-5
N-((1S,2S)-2-aminocyclohexyl)-N'-(3,5-bis(trifluoromethyl)phenyl)thiourea

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1027477-04-8
(S)-N-Boc-((1S,2S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)cyclohexyl)pyrrolidine-2-carboxamide

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

With chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h;

N-((1S,2S)-2-aminocyclohexyl)-N'-(3,5-bis(trifluoromethyl)phenyl)thiourea; In tetrahydrofuran; at 0 ℃; for 12h;
DOI:10.3998/ark.5550190.0011.229