N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide

Base Information

• Chemical Name: N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide
• CAS No.: 313342-12-0
• Molecular Formula: C7H13F3N2O2S
• Molecular Weight: 246.25
• Mol file: 313342-12-0.mol

Synonyms:N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide;Methanesulfonamide, N-[(1S,2S)-2-aminocyclohexyl]-1,1,1-trifluoro-

Chemical Property of N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide

Chemical Property:

• Boiling Point: 269.7±50.0 °C(Predicted)
• PKA: 5.43±0.20(Predicted)
• PSA: 0.00000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide

There total 2 articles about N-[(1S,2S)-2-aMinocyclohexyl]-1,1,1-trifluoro-MethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzyl (1S,2S)-2-(trifluoromethylsulfonamido)cyclohexylcarbamate (1160841-06-4) → N-((1S,2S)-2-aminocyclohexyl)trifluoromethanesulfonamide (313342-12-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 10h;

DOI:10.1002/adsc.200800445

Reference yield: 31.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-((1R,2R)-2-aminocyclohexyl)isoindoline-1,3-dione (438588-60-4) → N-((1R,2R)-2-aminocyclohexyl)-1,1,1-trifluoromethanesulfonamide (1023284-00-5,313342-12-0)

Guidance literature:

trifluoromethylsulfonic anhydride; 2-((1R,2R)-2-aminocyclohexyl)isoindoline-1,3-dione; In dichloromethane; at 0 ℃; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water;

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tetasy.2009.11.029

upstream raw materials:

benzyl (1S,2S)-2-(trifluoromethylsulfonamido)cyclohexylcarbamate

trifluoromethylsulfonic anhydride

2-((1R,2R)-2-aminocyclohexyl)isoindoline-1,3-dione

Refernces

• 1、 Xue, Fei,Zhang, Shilei,Duan, Wenhu,Wang, Wei. "A novel bifunctional sulfonamide primary amine-catalyzed enantioselective conjugate addition of ketones to nitroolefins". supporting information; experimental part. p. 2194 - 2198. Retrieved 2009/10/02.