N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Base Information

Chemical Name:N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea
CAS No.:1217436-37-7
Molecular Formula:C23H19F6N3S
Molecular Weight:483.48
Hs Code.:
Mol file:1217436-37-7.mol

Synonyms:1-[(1S,2S)-2-amino-1,2-diphenylethyl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea;

Suppliers and Price of N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

Chemical Property:

Melting Point:68-69 °C
Boiling Point:487.6±55.0 °C(Predicted)
PKA:11.51±0.70(Predicted)
PSA：82.17000
Density:1.384±0.06 g/cm3(Predicted)
LogP:7.61610

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea

There total 1 articles about N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 29841-69-8
(S,S)-1,2-diphenyl-1,2-diaminoethane

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1217436-37-7
1-[(1S,2S)-2-amino-1,2-diphenylethyl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

Guidance literature:: (S,S)-1,2-diphenyl-1,2-diaminoethane; With hydrogenchloride; In diethyl ether; for 1h; Schlenk technique; Inert atmosphere;

3,5-bistrifluoromethylphenylisothiocyanate; In diethyl ether; at 20 ℃; for 48h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejoc.201402871

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1217436-37-7
1-[(1S,2S)-2-amino-1,2-diphenylethyl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

: 1279128-86-7
tert-butyl (S)-2-[(1S,2S)-2-{3-[3,5-bis(trifluoromethyl)phenyl]thioureido}-1,2-diphenylethylcarbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

With chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-[(1S,2S)-2-amino-1,2-diphenylethyl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea; In tetrahydrofuran; at 0 ℃; for 12h;
DOI:10.3998/ark.5550190.0011.229

Reference yield:

: 1217436-37-7
1-[(1S,2S)-2-amino-1,2-diphenylethyl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

: 1228042-82-7
(S)-N-((1S,2S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-1,2-diphenylethyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

2: hydrogenchloride; methanol / 1 h / 20 °C

With hydrogenchloride; methanol; dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1002/ejoc.201001417