N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[(1R)-1-(1-naphthalenyl)ethyl]-Thiourea

Base Information

• Chemical Name: N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[(1R)-1-(1-naphthalenyl)ethyl]-Thiourea
• CAS No.: 313695-70-4
• Molecular Formula: C27H27N3S
• Molecular Weight: 425.58838
• Mol file: 313695-70-4.mol

Synonyms:1-((1S,2S)-2-Amino-1,2-diphenyl-ethyl)-3-((R)-1-naphthalen-1-yl-ethyl)-thiourea;

Chemical Property of N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[(1R)-1-(1-naphthalenyl)ethyl]-Thiourea

Chemical Property:

• Boiling Point: 599.4±60.0 °C(Predicted)
• PKA: 12.92±0.70(Predicted)
• PSA: 82.17000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 7.28830

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthalenyl)ethyl]thiourea, 98%, (99% ee) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[(1R)-1-(1-naphthalenyl)ethyl]-Thiourea

There total 2 articles about N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[(1R)-1-(1-naphthalenyl)ethyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(1-Naphthyl)ethylamine (3886-70-2) → N-[(1S,2S)-2-amino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthyl)ethyl]thiourea (313695-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DCC / diethyl ether / 15 h / -10 - 20 °C

2: 80 percent / CH₂Cl₂ / 20 °C

With dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;

DOI:10.1039/b517937h

Reference yield:

((R)-1-Naphthalen-2-yl-ethyl)-dithiocarbamic acid; compound with triethyl-amine → N-[(1S,2S)-2-amino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthyl)ethyl]thiourea (313695-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-chloro-1,3-dimethylimidazolinium chloride / CH₂Cl₂ / 1 h / 20 °C

2: 53 percent / benzene / 24 h / 20 °C

With 2-chloro-1,3-dimethylimidazolinium chloride; In dichloromethane; benzene; 1: Elimination / 2: Substitution;

DOI:10.1021/jo000745n

Reference yield: 85.0%

N-[(1S,2S)-2-amino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthyl)ethyl]thiourea (313695-70-4) + di-tert-butyl dicarbonate (24424-99-5) → N-[(1S,2S)-2-tert-butoxycarbonylamino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthyl)ethyl]thiourea (313695-81-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo000745n

upstream raw materials:

(R)-1-(1-Naphthyl)ethylamine

Downstream raw materials:

N-[(1S,2S)-2-tert-butoxycarbonylamino-1,2-diphenylethyl]-N'-[(R)-1-(1-naphthyl)ethyl]thiourea

(4S,5S)-1-tert-butoxycarbonyl-4,5-diphenyl-2-[(R)-1-(1-naphthyl)ethylimino]imidazolidine