N,N'-(1R,2R)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)] -Thiourea

Base Information

• Chemical Name: N,N'-(1R,2R)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)] -Thiourea
• CAS No.: 743458-79-9
• Molecular Formula: C₂₄H₂₀F₁₂N₄S₂
• Molecular Weight: 656.562
• Mol file: 743458-79-9.mol

Synonyms:Thiourea, N,N''-(1R,2R)-1,2-cyclohexanediylbis[N'-[3,5-bis(trifluoromethyl)phenyl]-;

Chemical Property of N,N'-(1R,2R)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)] -Thiourea

Chemical Property:

• Melting Point: 132-133 °C (decomp)(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 504.7±60.0 °C(Predicted)
• PKA: 11.46±0.70(Predicted)
• PSA: 112.30000
• Density: 1.53±0.1 g/cm3(Predicted)
• LogP: 9.27380

Purity/Quality:

97% ^*data from raw suppliers

N,N'-(1R,2R)-1,2-Cyclohexanediylbis[N'-[3,5-bis(trifluoromethyl)phenyl]thiourea], 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-(1R,2R)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)] -Thiourea

There total 8 articles about N,N'-(1R,2R)-1,2-cyclohexanediyl bis[N'-[3,5-bis(trifluoroMethyl)phenyl)] -Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) + trans-1,2-cyclohexanediamine → 1,1'-((1S,2S)-cyclohexane-1,2-diyl)bis(3-(3,5bis(trifluoromethyl)phenyl)thiourea) (1140969-69-2,743458-79-9)

Guidance literature:

In dichloromethane; for 72h; Inert atmosphere;

DOI:10.1080/10610278.2013.806809

Reference yield: 97.0%

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) + 3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) → 1,1’-((1R,2R)-cyclohexane-1,2-diyl)bis(3-(3,5-bis(trifluoromethyl)phenyl) thiourea) (743458-79-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/adsc.201701224

Reference yield: 95.0%

3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) + trans-1,2-Diaminocyclohexane (1121-22-8,1436-59-5,20439-47-8,21436-03-3,41013-43-8,694-83-7) → 1,1’-((1R,2R)-cyclohexane-1,2-diyl)bis(3-(3,5-bis(trifluoromethyl)phenyl) thiourea) (743458-79-9)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jf505355r

upstream raw materials:

(1R,2R)-1,2-diaminocyclohexane

3,5-bistrifluoromethylphenylisothiocyanate

trans-1,2-Diaminocyclohexane

(S,S)-1,2-diaminocyclohexane