6-Chloro-2-cyclopropylnicotinic acid

Base Information

• Chemical Name: 6-Chloro-2-cyclopropylnicotinic acid
• CAS No.: 862695-75-8
• Molecular Formula: C9H8ClNO2
• Molecular Weight: 197.61832
• Mol file: 862695-75-8.mol

Synonyms:6-Chloro-2-cyclopropylnicotinic acid

Chemical Property of 6-Chloro-2-cyclopropylnicotinic acid

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-cyclopropylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-2-cyclopropylnicotinic acid

There total 5 articles about 6-Chloro-2-cyclopropylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-chloro-2-cyclopropyl-nicotinic acid methyl ester (862695-74-7) → 6-chloro-2-cyclopropyl-nicotinic acid (862695-75-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 25 ℃; for 3h;

DOI:10.1016/j.bmcl.2012.08.070

Reference yield:

methyl 3-cyclopropyl-3-oxopropanoate (32249-35-7) → 6-chloro-2-cyclopropyl-nicotinic acid (862695-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium acetate / methanol / 48 h / 25 °C

2: toluene / 20 h / 100 °C

3: sodium t-butanolate / 30 h / 145 °C

4: O-phenyl phosphorodichloridate / 0.17 h / 180 °C

5: sodium hydroxide / methanol; water / 3 h / 25 °C

With ammonium acetate; O-phenyl phosphorodichloridate; sodium hydroxide; sodium t-butanolate; In methanol; water; toluene; 2: |Michael Addition;

DOI:10.1016/j.bmcl.2012.08.070

Reference yield:

3-amino-3-cyclopropyl-acrylic acid methyl ester (862695-71-4) → 6-chloro-2-cyclopropyl-nicotinic acid (862695-75-8)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 20 h / 100 °C

2: sodium t-butanolate / 30 h / 145 °C

3: O-phenyl phosphorodichloridate / 0.17 h / 180 °C

4: sodium hydroxide / methanol; water / 3 h / 25 °C

With O-phenyl phosphorodichloridate; sodium hydroxide; sodium t-butanolate; In methanol; water; toluene; 1: |Michael Addition;

DOI:10.1016/j.bmcl.2012.08.070

upstream raw materials:

6-chloro-2-cyclopropyl-nicotinic acid methyl ester

methyl 3-cyclopropyl-3-oxopropanoate

3-amino-3-cyclopropyl-acrylic acid methyl ester

4-(1-amino-1-cyclopropyl-methylene)-pent-2-enedioic acid dimethyl ester

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