7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester

Base Information

• Chemical Name: 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester
• CAS No.: 147611-04-9
• Molecular Formula: C₂₁H₃₀N₂O₄
• Molecular Weight: 374.48
• Hs Code.: 2933990090
• Mol file: 147611-04-9.mol

Synonyms:benzyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]-7-azaspiro[3.5]nonane-7-carboxylate;7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, phenylMethyl ester

Chemical Property of 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester

Chemical Property:

• PSA: 71.36000
• LogP: 4.23480

Purity/Quality:

98%min ^*data from raw suppliers

benzyl2-[(2-methylpropan-2-yl)oxycarbonylamino]-7-azaspiro[3.5]nonane-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester

There total 1 articles about 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate (147611-02-7) → benzyl 2-[(tert-butoxycarbonyl)amino]-7-azaspiro[3.5]nonane-7-carboxylate (147611-04-9)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; Inert atmosphere;

Reference yield:

benzyl 2-[(tert-butoxycarbonyl)amino]-7-azaspiro[3.5]nonane-7-carboxylate (147611-04-9) → benzyl 2-(methylamino)-7-azaspiro[3.5]nonane-7-carboxylate hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 30 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 2 h / 30 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

benzyl 2-[(tert-butoxycarbonyl)amino]-7-azaspiro[3.5]nonane-7-carboxylate (147611-04-9) → benzyl 2-{[(cyclopropylmethyl)sulfonyl](methyl)amino}-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 30 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 2 h / 30 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2.5 h / 28 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

upstream raw materials:

di-tert-butyl dicarbonate

benzyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate

Refernces