9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE

Base Information

Chemical Name:9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE
CAS No.:1188331-74-9
Molecular Formula:C12H15BrN2
Molecular Weight:267.16
Hs Code.:
Mol file:1188331-74-9.mol

Synonyms:9-bromo-1,3,4,6,7,11b-hexahydro-2H-Pyrazino[2,1-a]isoquinoline;2H-Pyrazino[2,1-a]isoquinoline, 9-bromo-1,3,4,6,7,11b-hexahydro-;9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE

Suppliers and Price of 9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE

Chemical Property:

PSA：15.27000
LogP:3.82220

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE

There total 7 articles about 9-BROMO-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: tert-butyl (11bR)-9-bromo-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline-2-carboxylate

: 1188331-74-9
(11bR)-9-bromo-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 - 60 ℃; for 14h;

Reference yield:

: tert-butyl (11bR)-9-bromo-4-oxo-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinoline-2-carboxylate

: 1188331-74-9
(11bR)-9-bromo-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 14 h / 20 - 60 °C

With hydrogenchloride; borane-THF; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 58971-11-2
2-(3-bromophenyl)ethanamine

: 1188331-74-9
(11bR)-9-bromo-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / dichloromethane / 0 °C

2: toluene / 2 h / Reflux

3: sulfuric acid / dichloromethane; water / 0.5 h / 0 - 20 °C

4: Chiralpak AD-H / methanol / Resolution of racemate

5: triethylamine / dichloromethane / 16 h / 20 °C

6: borane-THF / tetrahydrofuran / 16 h / 20 °C

7: hydrogenchloride / 1,4-dioxane / 14 h / 20 - 60 °C

With hydrogenchloride; borane-THF; sulfuric acid; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;