4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid

Base Information

Chemical Name:4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid
CAS No.:706813-28-7
Molecular Formula:C₂₈H₃₃F₃N₂O₄
Molecular Weight:518.576
Hs Code.:
Mol file:706813-28-7.mol

Synonyms:Reaxys Registry NuMber: 10219397;4-((9-(tert-butyl)-2-oxo-3-(4-(trifluoroMethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)Methyl)benzoic acid;4-({Trans-8-tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]dec-1-yl }methyl)benzoic acid;Benzoic acid, 4-[[(6α,9β)-9-(1,1-dimethylethyl)-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undec-1-yl]methyl]-

Suppliers and Price of 4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid

Chemical Property:

PSA：70.08000
LogP:7.09370

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid

There total 8 articles about 4-((9-(Tert-butyl)-2-oxo-3-(4-(trifluoromethoxy)phenyl)-1,3-diazaspiro[5.5]undecan-1-yl)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 706813-27-6
4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid tert-butyl ester

: 706813-28-7
4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2005.06.101

Reference yield:

: 706813-21-0
(1-amino-4-tert-butyl-cyclohexyl)-acetonitrile

: 706813-28-7
4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 20 °C

2: NaH / benzene / 20 °C

3: aq. HCl / ethanol / Heating

4: LiAlH₄; AlCl₃ / diethyl ether / 20 °C

5: NaH / dimethylformamide / 20 °C

6: TFA / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; sodium hydride; trifluoroacetic acid; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2005.06.101

Reference yield:

: 706813-26-5
9-tert-butyl-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undecan-2-one

: 706813-28-7
4-[9-tert-butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 20 °C

2: TFA / CH₂Cl₂ / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.06.101