(1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:(1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
CAS No.:207405-69-4
Molecular Formula:C11H19NO3
Molecular Weight:213.277
Hs Code.:

Synonyms:207405-69-4;(1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;tert-Butyl (1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;198835-03-9;Rel-(1r,4r,5s)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5S)-rel-;(1R,4R,5S)-2-Boc-5-hydroxy-2-azabicyclo[2.2.1]heptane;SCHEMBL12276853;rel-tert-Butyl (1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;rel-tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;MFCD22209794;CS-0102522;W19415;t-Butyl (1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;(1R,4R,5S)-rel-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;(1R,4R,5S)-rel-tert-Butyl5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;(5S)-TERT-BUTYL 5-HYDROXY-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE

Suppliers and Price of (1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:213.13649347
Heavy Atom Count:15
Complexity:272

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC2CC1CC2O
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@H]2C[C@@H]1C[C@@H]2O

Technology Process of (1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

There total 5 articles about (1R,4R,5S)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 702666-73-7
tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate

: 207405-69-4,198835-03-9,198835-07-3,1932042-59-5
(1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate

Guidance literature:: tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; at 23 ℃; for 0.5h; Inert atmosphere;

With dimethyl sulfate; In tetrahydrofuran; at 35 ℃; for 4h;

With water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 23 ℃; for 1h;

Reference yield:

: (+/-)-tert-butyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate

: 1099570-25-8,198835-02-8,198835-05-1,207405-59-2
rac-tert-butyl (1R,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1099570-25-8,198835-02-8,198835-05-1,207405-59-2
rac-tert-butyl (1R,4S,6S)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1099570-25-8,198835-02-8,198835-05-1,207405-59-2
(1S,4R,6R)-tert-butyl 6-hydroxy-2-azabicyclo[2,2,1]heptane-2-carboxylate

: 198835-01-7,1099570-25-8,198835-02-8,198835-05-1,207405-59-2
(1S,4R,6S)-tert-butyl 6-hydroxy-2-azabicyclo[2,2,1]heptane-2-carboxylate

: 198835-03-9,198835-07-3,1932042-59-5
C₁₁H₁₉NO₃

: 198835-03-9,198835-07-3,1932042-59-5
tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 207405-69-4,198835-03-9,198835-07-3,1932042-59-5
(1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate

: 198835-03-9,198835-07-3,1932042-59-5
(1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: (+/-)-tert-butyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; With mercury(II) diacetate; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h;

With sodium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃;