Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Base Information

• Chemical Name: Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
• CAS No.: 17366-48-2
• Molecular Formula: C7 H14ClNO
• Molecular Weight: 163.647
• Mol file: 17366-48-2.mol

Synonyms:AC-1981;8-Aza-bicyclo[3.2.1]octan-3-ol HCl;exo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride;

Chemical Property of Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Chemical Property:

• PSA: 32.26000
• LogP: 1.39250
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(3-exo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

There total 5 articles about Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (194222-05-4) → (1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (17366-48-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

Reference yield:

→ Mortropin-hydrochlorid (14383-51-8,17366-48-2)

Guidance literature:

Vinyloxycarbonylverbindung (4b), HCl in Essigsaeure;

DOI:10.1016/S0040-4039(01)93104-1

Reference yield:

pseudotropine (135-97-7) → (1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (17366-48-2)

Guidance literature:

upstream raw materials:

pseudotropine

(1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

N-Boc-nortropinone

N-benzylnortropinone

Downstream raw materials:

(1R,3S,5S)-8-(4-iodophenyl)-8-azabicyclo[3.2.1]octan-3-ol

(1R,3S,5S)-8-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-8-azabicyclo[3.2.1]octan-3-ol

exo-8-[1-(diphenylmethyl)azetidin-3-yl]-8-azabicyclo[3.2.1]octan-3-ol