Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-

Base Information

Chemical Name:Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-
CAS No.:1185503-48-3
Molecular Formula:C20H18F7NO2
Molecular Weight:437.357
Hs Code.:
Mol file:1185503-48-3.mol

Synonyms:

Suppliers and Price of Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 9 raw suppliers

Chemical Property of Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-

There total 13 articles about Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

: 1185503-45-0
C₂₀H₁₆F₇NO₂

: 1185503-48-3
(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 16h;

Reference yield:

: 1523569-83-6
C₂₈H₂₄F₇NO₂

: 1185503-48-3
(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

: 327623-37-0
(2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In methanol; at 20 ℃; for 5h; Overall yield = 98 %;
DOI:10.1016/j.cclet.2013.07.017

Reference yield:

: 1185503-37-0
C₁₉H₁₈Cl₃FN₂O₂

: 1185503-48-3
(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran; toluene / 1 h / -5 °C

2.1: hydrogen; toluene-4-sulfonic acid / palladium 10% on activated carbon / methanol / 2.5 h

3.1: N-chloro-succinimide; potassium carbonate / N,N-dimethyl-formamide / 0.33 h / -10 °C

3.2: 0.83 h / -10 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h

With N-chloro-succinimide; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;