(3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

Base Information

• Chemical Name: (3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate
• CAS No.: 370880-09-4
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.292
• Mol file: 370880-09-4.mol

Synonyms:tert-butyl (3aR,6aR)-hexahydro-pyrrolo[3,4-b]pyrrole-1-carboxylate;tert-butyl (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate;tert-butyl (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate;(3aR,6aR)-hexahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester;(3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate;(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester;(3aR,6aR)-hexahydro-pyrrolo[3,4-b]-pyrrole-1-carboxylic acid tert-butyl ester;(3aR,6aR)-hexahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid 1,1-dimethyl-ethyl ester;

Chemical Property of (3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

Chemical Property:

• Boiling Point: 295.4±13.0 °C(Predicted)
• PKA: 10.66±0.20(Predicted)
• PSA: 41.57000
• Density: 1.076±0.06 g/cm3(Predicted)
• LogP: 1.48190
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(3aR,6aR)-Hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

There total 1 articles about (3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3aR,6aR)-5-(trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate (370880-08-3,1279815-99-4) → (3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester (370880-09-4,1018443-32-7)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; water; toluene;

Reference yield: 18.0%

(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester (370880-09-4,1018443-32-7) + 2-(benzylthio)-5-phenyl-1,3,4-oxadiazole (28923-53-7) → (3aR,6aR)-5-(5-phenyl-[1,3,4]oxadiazol-2-yl)-hexahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-benzene; at 220 ℃; for 0.25h; Microwave;

Reference yield:

(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester (370880-09-4,1018443-32-7) + 5-bromo-2-chloro-3-methylpyridine (29241-60-9) → tert-butyl (3AR,6AR)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate (370880-43-6)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;

upstream raw materials:

tert-butyl (3aR,6aR)-5-(trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate

Downstream raw materials:

tert-butyl (3AR,6AR)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

(3aR,6aR)-1-(4-bromo-phenyl)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole

(3aR,6aR)-5-methyl-1-(4-piperazin-1-yl-phenyl)-octahydro-pyrrolo[3,4-b]pyrrole

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