Chemical Property of 4-Amino-[2,3'-bithiophene]-5-carboxamide
Chemical Property:
- Melting Point:209-211°C
- Boiling Point:399.2oC at 760 mmHg
- Flash Point:195.2oC
- PSA：125.59000
- Density:1.45g/cm3
- LogP:3.43920
- Storage Temp.:Store at +4°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:224.00780523
- Heavy Atom Count:14
- Complexity:237
- Purity/Quality:
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99%, *data from raw suppliers
SC-514 *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
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Description
SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1
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Uses
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
