(S)-N-Fmoc-2-(6'-octenyl)glycine

Base Information

• Chemical Name: (S)-N-Fmoc-2-(6'-octenyl)glycine
• CAS No.: 1058705-57-9
• Molecular Formula: C24H27NO4
• Molecular Weight: 393.483
• Hs Code.: 2922498590
• Mol file: 1058705-57-9.mol

Synonyms:(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}non-8-enoic acid;(S)-N-Fmoc-2-(6'-octenyl)glycine;Fmoc-S7H-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)non-8-enoic acid;(S)-N-Fmoc-2-(6'-heptenyl)glycine;(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)NON-8-ENOIC ACID,97%;

Chemical Property of (S)-N-Fmoc-2-(6'-octenyl)glycine

Chemical Property:

• Boiling Point: 610.7±55.0 °C(Predicted)
• PKA: 3.90±0.21(Predicted)
• PSA: 75.63000
• Density: 1.168±0.06 g/cm3(Predicted)
• LogP: 5.50570
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}non-8-enoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: (S)-N-Fmoc-2-(6'-octenyl)glycine is a chemical compound with various applications across different fields. In the field of organic chemistry and peptide synthesis, it serves as a valuable building block for the creation of custom-designed peptides and proteins. Its unique chemical structure, with the Fmoc (9-fluorenylmethoxycarbonyl) protecting group and the octenyl side chain, allows for precise and controlled peptide assembly, enabling the synthesis of peptide sequences used in drug development, biochemical research, and biotechnology. Additionally, in the pharmaceutical industry, this compound may find use in the development of novel drug candidates or as an essential component in the synthesis of peptide-based pharmaceuticals. Its role and significance can vary depending on specific research or industrial needs within each field, highlighting its potential versatility and importance in diverse scientific endeavors.

Technology Process of (S)-N-Fmoc-2-(6'-octenyl)glycine

There total 1 articles about (S)-N-Fmoc-2-(6'-octenyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H29NO4 → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)non-8-enoic acid (1058705-57-9)

Guidance literature:

With hydrogenchloride; C₂₁H₂₃NO₄; water; In 1,4-dioxane; Reflux;

DOI:10.1016/j.bmcl.2009.10.128

Reference yield:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)non-8-enoic acid (1058705-57-9) → (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}nonanoic acid (1262886-65-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2010.09.074

Reference yield:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)non-8-enoic acid (1058705-57-9) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)non-8-enoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 6 h / 110 °C / Molecular sieve

2: trifluoroacetic acid; triethylsilane / chloroform / 2 h / 20 °C

With triethylsilane; toluene-4-sulfonic acid; trifluoroacetic acid; In chloroform; toluene;

Downstream raw materials:

(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}nonanoic acid

Refernces