(R)-Telomestatin

Base Information

• Chemical Name: (R)-Telomestatin
• CAS No.: 265114-54-3
• Molecular Formula: C26H14N8O7S
• Molecular Weight: 582.5
• DSSTox Substance ID: DTXSID50474656
• Nikkaji Number: J2.367.475K
• Wikipedia: Telomestatin
• Wikidata: Q4391972
• Mol file: 265114-54-3.mol

Synonyms:telomestatin

Chemical Property of (R)-Telomestatin

Chemical Property:

• Appearance/Colour: Solid powder
• PKA: 0.31±0.20(Predicted)
• PSA: 219.87000
• Density: 2.01±0.1 g/cm3(Predicted)
• LogP: 5.20510
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 0
• Exact Mass: 582.07061599
• Heavy Atom Count: 42
• Complexity: 1070

Purity/Quality:

98% min ^*data from raw suppliers

Telomestatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C2C3=NC(=C(O3)C)C4=NC(=CO4)C5=NC(=CO5)C6=NC(=CO6)C7=NC(=CO7)C8=NC(=CO8)C9=NC(CS9)C(=N2)O1
• Isomeric SMILES: CC1=C2C3=NC(=C(O3)C)C4=NC(=CO4)C5=NC(=CO5)C6=NC(=CO6)C7=NC(=CO7)C8=NC(=CO8)C9=N[C@@H](CS9)C(=N2)O1
• Uses: Telomostatin is a potent and very specific telomerase inhibitor, acting solely on human telomere sequences without affecting both DNA polymerases or reverse transcriptases.

Technology Process of (R)-Telomestatin

There total 23 articles about (R)-Telomestatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.3%

C45H30N8O8S → Telomestatin (265114-54-3)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 72h;

Reference yield: 20.0%

C30H24N8O8S (912656-63-4) → telomestatin (265114-54-3)

Guidance literature:

With trifluoromethylsulfonic anhydride; methoxybenzene; Triphenylphosphine oxide; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1021/ol061793i

Reference yield: 20.0%

C33H22N8O8S (1038926-34-9) → telomestatin (265114-54-3)

Guidance literature:

With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; methoxybenzene; at 20 ℃;

DOI:10.1039/b802477d

upstream raw materials:

C₃₀H₂₄N₈O₈S

(S)-2-[3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]oxazole-4-carboxylic acid

(S)-methyl 2-[3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]oxazole-4-carboxylate

(R)-methyl 2-(1-(tert-butoxycarbonylamino)-2-(tert-butylthio)ethyl)-5-methyloxazole-4-carboxylate

Refernces

• 1、 Doi, Takayuki,Yoshida, Masahito,Shin-Ya, Kazuo,Takahashi, Takashi. "Total synthesis of (R)-telomestatin". . p. 4165 - 4167. Retrieved 2007/10/03.