FMoc-β-Lys(Boc)-OH

Base Information

• Chemical Name: FMoc-β-Lys(Boc)-OH
• CAS No.: 219967-68-7
• Molecular Formula: C26H32N2O6
• Molecular Weight: 468.54
• Mol file: 219967-68-7.mol

Synonyms:N|A-Fmoc-N?-Boc-L-|A-lysine;(S)-6-(tert-Butoxycarbonylamino)-3-(fluoren-9-ylmethoxycarbonylamino)hexanoic acid;Fmoc-L-|A-HomoOrn(Boc)-OH;Fmoc-|A-Lys(Boc)-OH;

Chemical Property of FMoc-β-Lys(Boc)-OH

Chemical Property:

• Boiling Point: 689.3±55.0 °C(Predicted)
• PKA: 4.38±0.10(Predicted)
• PSA: 120.94000
• Density: 1.210±0.06 g/cm3(Predicted)
• LogP: 5.08210
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-L-beta-Lys(Boc)-OH 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 38

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMoc-β-Lys(Boc)-OH

There total 2 articles about FMoc-β-Lys(Boc)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(S)-6-<<(tert-butoxy)carbonyl>amino>-1-diazo-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)hexan-2-one → Fmoc-(S)-β3-hOrn(Boc)-OH (219967-68-7)

Guidance literature:

With 4-methyl-morpholine; water; silver trifluoroacetate; In tetrahydrofuran; for 4h; 0 deg C to RT;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5

Reference yield:

Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) → Fmoc-(S)-β3-hOrn(Boc)-OH (219967-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) i-BuOCOCl, N-methylmorpholine / 1.) THF, -20 deg C, 20 min; 2.) THF, Et₂O, -5 deg C to RT, 4 h

2: 63 percent / H₂O, CF₃COOAg, N-methylmorpholine / tetrahydrofuran / 4 h / 0 deg C to RT

With 4-methyl-morpholine; water; silver trifluoroacetate; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5

Reference yield:

Fmoc-(S)-β3-hOrn(Boc)-OH (219967-68-7) → C32H42N4O8

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 4 h / 20 °C

2: 2.67 g / iPr₂NEt / dioxane; formamide / 48 h

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; formamide;

DOI:10.1002/chem.200305571

upstream raw materials:

Fmoc-Orn(Boc)-OH

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