1H,2H,3H,4H,5H-Pyrido[2,3-b][1,4]diazepin-2-one

Base Information

• Chemical Name: 1H,2H,3H,4H,5H-Pyrido[2,3-b][1,4]diazepin-2-one
• CAS No.: 757966-64-6
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Hs Code.: 2933990090
• Mol file: 757966-64-6.mol

Synonyms:1H,2H,3H,4H,5H-pyrido[2,3-b][1,4]diazepin-2-one;4,5-Dihydro-1H-pyrido[2,3-b][1,4]diazepin-2(3H)-one;4,5-dihydro-1H-pyrido[3,2-b][1,4]diazepin-2(3H)-one;1,3,4,5-Tetrahydro-2H-pyrido[2,3-b][1,4]diazepin-2-one

Chemical Property of 1H,2H,3H,4H,5H-Pyrido[2,3-b][1,4]diazepin-2-one

Chemical Property:

• PSA: 57.51000
• LogP: 1.05880

Purity/Quality:

97% ^*data from raw suppliers

4,5-Dihydro-1H-pyrido[2,3-b][1,4]diazepin-2(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H,2H,3H,4H,5H-Pyrido[2,3-b][1,4]diazepin-2-one

There total 2 articles about 1H,2H,3H,4H,5H-Pyrido[2,3-b][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(3-nitro-2-pyridinyl)amino]propanoic acid ethyl ester (136742-53-5) → 1,3,4,5-tetrahydro-pyrido[3,4-b][1,4]diazepin-2-one (757966-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / Pd/C / ethanol / 2 h / 20 °C / 1125.09 Torr

2: 1.99 g / aq. HOAc / 4 h / Heating

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmc.2004.03.023

Reference yield:

3-(3-Amino-pyridin-2-ylamino)-propionic acid ethyl ester (136742-54-6) → 1,3,4,5-tetrahydro-pyrido[3,4-b][1,4]diazepin-2-one (757966-64-6)

Guidance literature:

With acetic acid; for 4h; Heating;

DOI:10.1016/j.bmc.2004.03.023

Reference yield:

1,3,4,5-tetrahydro-pyrido[3,4-b][1,4]diazepin-2-one (757966-64-6) → 2-(4-phenyl-piperazin-1-yl)-4,5-dihydro-3H-pyrido[3,4-b][1,4]diazepine

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅; pyridine / various solvent(s) / 4 h / 135 °C

2: 74 mg / ethanol / 4 h / Heating

With pyridine; phosphorus pentachloride; In ethanol;

DOI:10.1016/j.bmc.2004.03.023

upstream raw materials:

3-(3-Amino-pyridin-2-ylamino)-propionic acid ethyl ester

3-[(3-nitro-2-pyridinyl)amino]propanoic acid ethyl ester

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