(S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride

Base Information

• Chemical Name: (S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride
• CAS No.: 72747-20-7
• Molecular Formula: C11H16ClNO3
• Molecular Weight: 245.706
• Hs Code.: 2922509090
• Mol file: 72747-20-7.mol

Synonyms:(S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride;

Chemical Property of (S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride

Chemical Property:

• PSA: 61.55000
• LogP: 2.24030
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl2-amino-3-(3-methoxyphenyl)propanoatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride

There total 1 articles about (S)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formyl-L-m-methoxyphenylalanine methyl ester (72683-82-0) → L-m-methoxyphenylalanine methyl ester hydrochloride (72747-20-7)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 4h; Yield given;

DOI:10.1021/jm00178a013

Reference yield: 90.0%

Z-Asp(OBzl)-OH (3479-47-8) + L-m-methoxyphenylalanine methyl ester hydrochloride (72747-20-7) → N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-L-m-methoxyphenylalanine methyl ester

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 14h;

DOI:10.1021/jm00178a013

Reference yield:

L-m-methoxyphenylalanine methyl ester hydrochloride (72747-20-7) → L-aspartyl-L-m-methoxyphenylalanine methyl ester (72683-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N, DCC, 1-hydroxybenzotriazole / CHCl₃ / 14 h / 0 - 20 °C

2: 58 percent / H₂ / 10percent Pd/C / methanol / 12 h / 760 Torr / Ambient temperature

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1021/jm00178a013

upstream raw materials:

N-formyl-L-m-methoxyphenylalanine methyl ester

Downstream raw materials:

L-aspartyl-L-m-methoxyphenylalanine methyl ester