Chemical Property of Rapastinel
Chemical Property:
- Boiling Point:844.212 °C at 760 mmHg
- PKA:12.26±0.45(Predicted)
- Flash Point:464.363 °C
- PSA：179.29000
- Density:1.37 g/cm3
- LogP:-1.30530
- Storage Temp.:?20°C
- XLogP3:-2.8
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:413.22743373
- Heavy Atom Count:29
- Complexity:659
- Purity/Quality:
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98% *data from raw suppliers
GLYX 13 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C(C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)N)N)O
- Isomeric SMILES:C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H]([C@@H](C)O)C(=O)N)N)O
- Recent ClinicalTrials:Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness
- Recent EU Clinical Trials:A Randomized, Double-blind, Placebo- and Active- controlled, Multicenter Study of Rapastinel as Monotherapy in Major Depressive Disorder
- Recent NIPH Clinical Trials:Study of monotherapy Rapastinel in the prevention of relapse in patients with Major Depressive Disorder (MDD)
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Uses
Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction. GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder. GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.
