3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-

Base Information

• Chemical Name: 3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-
• CAS No.: 691857-54-2
• Molecular Formula: C19H16FNO5S
• Molecular Weight: 389.404
• Mol file: 691857-54-2.mol

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)methanesulfonylamino]benzofuran-3-carboxylic acid methylamide;5-Cyclopropyl-2-(4-Fluorophenyl)-6-[(2-Hydroxyethyl)(Methylsulfonyl)amino]-N-Methyl-1-Benzofuran-3-Carboxamide;5-cyclopropyl-2-(4-fluorophenyl)-6-[N-(2-hydroxyethyl)methanesulfonylamino]benzofuran-3-carboxylic acid methylamide;5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid;Nesbuvir;Nesbuvir (USAN);5-cyclopropyl-2-(4-fluoro-phenyl)-6-methanesulfonylamino-benzofuran-3-carboxylic acid;HCV 796;

Chemical Property of 3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-

Chemical Property:

• PSA: 104.99000
• LogP: 5.33980

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Benzofurancarboxylicacid,5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-

There total 21 articles about 3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C20H18FNO7S2 (691857-55-3) → 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid (691857-54-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; Heating / reflux;

Reference yield:

ethyl 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(methylsulfonyl)methylsulfonamido)benzofuran-3-carboxylate → 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid (691857-54-2)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 6h;

Reference yield:

methyl 6-[bis(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxylate (1331942-99-4) → 5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid (691857-54-2)

Guidance literature:

methyl 6-[bis(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxylate; With water; potassium hydroxide; In ethanol; for 1h; Reflux;

With hydrogenchloride; In ethanol; water;

upstream raw materials:

C₂₀H₁₈FNO₇S₂

methyl 4-fluorobenzoyl acetate

p-benzoquinone

methyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate

Downstream raw materials:

5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

N,5-dicyclopropyl-2-(4-fluorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxamide