2',5-Dichloro-2-hydroxybenzophenone

Base Information

• Chemical Name: 2',5-Dichloro-2-hydroxybenzophenone
• CAS No.: 61785-35-1
• Molecular Formula: C13H8 Cl2 O2
• Molecular Weight: 267.111
• Hs Code.: 2914700090
• European Community (EC) Number: 262-965-6
• DSSTox Substance ID: DTXSID10210774
• Nikkaji Number: J310.576H
• Wikidata: Q83085547
• Mol file: 61785-35-1.mol

Synonyms:2',5-Dichloro-2-hydroxybenzophenone;61785-35-1;(5-chloro-2-hydroxyphenyl)-(2-chlorophenyl)methanone;(5-Chloro-2-hydroxyphenyl)(2-chlorophenyl)methanone;EINECS 262-965-6;4-chloro-2-(2-chlorobenzoyl)phenol;Methanone,(5-chloro-2-hydroxyphenyl)(2-chlorophenyl)-;SCHEMBL145258;DTXSID10210774;OSXVZDOVYCTYCW-UHFFFAOYSA-N;MFCD02682994;AKOS015889030;5-Chloro-2-hydroxy-2'-chlorobenzophenone;2',5-Dichloro-2-hydroxybenzophenone, 97%;D4703;FT-0640787;D90324;A833416;(2-chlorophenyl)-(5-chloro-2-hydroxyphenyl)-methanone;(5-chloranyl-2-oxidanyl-phenyl)-(2-chlorophenyl)methanone

Chemical Property of 2',5-Dichloro-2-hydroxybenzophenone

Chemical Property:

• Melting Point: 107-110 ºC(lit.)
• Boiling Point: 388.9 ºCat 760 mmHg
• Flash Point: 189 ºC
• PSA: 37.30000
• Density: 1.406 g/cm³
• LogP: 3.93000
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 265.9901349
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

98%,99%, ^*data from raw suppliers

2',5-Dichloro-2-hydroxybenzophenone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=C(C=CC(=C2)Cl)O)Cl

Technology Process of 2',5-Dichloro-2-hydroxybenzophenone

There total 1 articles about 2',5-Dichloro-2-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-chlorobenzoyl chloride (609-65-4) + 4-chloro-phenol (106-48-9,82344-39-6) → SL 81.0196 (61785-35-1)

Guidance literature:

With triethylamine; aluminium chloride; In dichloromethane; water; Petroleum ether;

Reference yield: 99.0%

SL 81.0196 (61785-35-1) + Diethyl 2-bromomalonate (685-87-0) → ethyl 5-chloro-3-(2-chlorophenyl)-1-benzofuran-2-carboxylate (1263152-60-8)

Guidance literature:

SL 81.0196; With potassium carbonate; In acetone; for 0.5h; Inert atmosphere;

Diethyl 2-bromomalonate; In acetone; Inert atmosphere; Reflux;

DOI:10.3987/COM-10-12070

Reference yield:

SL 81.0196 (61785-35-1) → C13H9Cl2NO (80018-05-9)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol202844c

upstream raw materials:

o-chlorobenzoyl chloride

4-chloro-phenol

Downstream raw materials:

4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenol

MT-189

ethyl 5-chloro-3-(2-chlorophenyl)-1-benzofuran-2-carboxylate

C₂₂H₁₈Cl₂N₂O₅S

Refernces