5-Amino-6-iodo-pyridine-2-carbonitrile

Base Information

• Chemical Name: 5-Amino-6-iodo-pyridine-2-carbonitrile
• CAS No.: 1079054-78-6
• Molecular Formula: C6H4IN3
• Molecular Weight: 245.02053
• Hs Code.: 2933399090
• Mol file: 1079054-78-6.mol

Synonyms:5-AMino-6-iodo-pyridine-2-carbonitrile;5-AMino-6-Methylpicolinonitrile;5-Amino-6-methyl-2-pyridinecarbonitrile

Chemical Property of 5-Amino-6-iodo-pyridine-2-carbonitrile

Chemical Property:

• Boiling Point: 361.0±42.0 °C(Predicted)
• PKA: 1.34±0.10(Predicted)
• PSA: 62.70000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 1.42508
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Amino-6-methylpicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-6-iodo-pyridine-2-carbonitrile

There total 2 articles about 5-Amino-6-iodo-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

dicyanozinc (557-21-1) + 3-amino-6-bromo-2-methylpyridine (126325-47-1) → 5-amino-6-methylpicolinonitrile (1079054-78-6)

Guidance literature:

With zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ISOPROPYLAMIDE; at 20 ℃; for 22h;

Reference yield:

zinc(II) cyanide (557-21-1) + 3-amino-6-bromo-2-methylpyridine (126325-47-1) → 5-amino-6-methylpicolinonitrile (1079054-78-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

5-amino-6-methylpicolinonitrile (1079054-78-6) → 4-((5-chloro-6-methylpyridin-2-yl)methylamino)-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)-2-methylpyridazin-3(2H)-one

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) chloride; tert.-butylnitrite / acetonitrile / 4 h / 20 - 60 °C / Inert atmosphere

2: cobalt(II) chloride; sodium tetrahydroborate / methanol / 0.5 h / 20 °C

3: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 4 h / 85 °C / Inert atmosphere

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert.-butylnitrite; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; cobalt(II) chloride; sodium t-butanolate; In methanol; toluene; acetonitrile;

upstream raw materials:

dicyanozinc

3-amino-6-bromo-2-methylpyridine

zinc(II) cyanide

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